Thursday, 1 August 2019

Indicaxanthin a chemo-active Phytochemical

By Kyle J. Norton

Chemotherapy is a type of therapy that use of drugs to destroy cancer cells by keeping them from proliferation and migration.

Under normal circumstance, cell growth is a natural process. Every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cells growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal growth rate again.

Cancer cells are fast-growing cells ignored the cell cycle inhibitors that stop the cell from growing after certain cell cycle division compared to normal cells. 

According to the statistics provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes. In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.

Conventionally, chemo drugs used for chemotherapy are powerful for the treatment of cancers, however, they also can cause damage to nearby healthy cell, leading to the serious adverse effects.

Cancer is a class of chronic diseases caused by cells growth and multiplies disorderedly and uncontrollably in the body.

Depending on the types and grade of cancer, some cancers can be progressively worse and damaged other healthy tissues. Sometimes cancers can spread to other tissues and organs in the body via lymph or blood.

The exact causes of cancer are unknown. Carcinoma accounting for over 90% of cancer diagnosed, is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands, including breast, prostate, lung, and colon.

Treatment of cancer conventionally is totally depending on types, grade and stage of cancer. Surgery, radiation and chemo drugs are used for the treatment in most cases of invasive cancer.

Indicaxanthin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

On finding a potential compound which processes chemo-activity, researchers examined the effect of Indicaxanthin as a natural chemoactive and chemopreventive agent.

According to the tested analysis, the bioactive compound showed significant activity neuromodulation and inflammatory regulation that prevent cellular damage.

Indicaxanthin protects the integrity of the neuron against alternation of cell DNA.

Moreover, the phytochemical also inhibited the overexpression of cancer tissues. Indicaxanthin inhibited the parameters associated with the cancer expression in the cells of breast, thyroid, and prostate cancer, including anti-proliferative activity.

More importantlyindicaxanthin also inhibited the proteins involved in the initiation and progression in the cancer cells.

Taken altogether, indicaxanthin may be considered a chemo active remedy, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Reverse screening on indicaxanthin from Opuntia ficus-indica as natural chemoactive and chemopreventive agent by Tutone M1, Virzì A2, Almerico AM2. (PubMed)

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