Thursday, 8 August 2019

Healthy Food Onion Protects the vascular endothelial Functioning Against Cardiovascular Disease

By Kyle J. Norton


Vasoprotection is the process to improve the function of the blood vessels, including the use of the herbal and natural remedy.

Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.

There 3 main types of the blood vessel are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.

The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.

The capillaries or the smallest blood vessels has been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.

Endothelial dysfunction is a condition characterized by the damage of the vascular endothelium, the thin layer of cells that lines blood vessels, a leading cause of the cardiovascular disease (CVD).

In other words, the vascular endothelium dysfunction reduced the function of targeting free radical that lead to the onset of oxidative stress.

Most common risk factors associated with vascular endothelium dysfunction are impaired vasodilation, deficiency of nitric oxide, and inflammation, and thrombosis.

Conventionally, treatments of vascular endothelial dysfunction are totally depending on the causes of the disease. Early detection has been found to play a critical role that recovers endothelial function".

Dr. Hirata Y. at The University of Tokyo.wrote, "Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function".

And, "There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes bodyweight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta-blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants".


The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient which processes vasoprotective activity researchers examined quercetin, a dietary polyphenol found abundantly in onion on vascular endothelial dysfunction (VED).

Epidemiologically, quercetin showed significant activity against the VED complication in the induction of oxidative stress, impaired vasodilation, platelet aggregation, and monocyte adhesion leading to the early event of morbidity and mortality in patients with cardiovascular disease (CVD).

Quercetin efficacy that protects against VED and decreases CVD risk was attributed to its antioxidant, vasodilatory, anti-platelet, and anti-atherogenic activities.

Futhermore, in vitro, quercetin exerted multiple actions on the NO-guanylyl cyclase pathway associated with the smooth muscle tone in bronchi or vessels, endothelium-derived hyperpolarizing factor(s) and endothelin-1 involved in vasoconstriction and endothelial function.

Moreover, the phytochemical also protected endothelial cells against apoptosis.

In vivo, quercetin prevented endothelial dysfunction by reducing blood pressure, oxidative stress and end-organ damage in hypertensive animals.

In other words, regular intake of quercetin improves the endothelium functioning against the risk of VED inducing cardiovascular disease, particularly in patients with hypertension and ischemic heart disease.

Taken altogether, onion processed a higher mount of quercetin may be considered a remedy for the prevention and treatment of vascular endothelial dysfunction, pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Vasoprotective activities of quercetin by Richard S Bruno. (Research Gate)
(2) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols by Perez-Vizcaino F1, Duarte J, Andriantsitohaina R. (PubMed)
(3) Diagnosis and treatment of endothelial dysfunction in cardiovascular disease by Hirata Y1, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R. (PubMed)

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