Sunday, 4 August 2019

Onion, the Natural Vasorelaxant Remedy

By Kyle J. Norton

Vasorelaxant is a term that refers to the reduction of vascular tension.

Vascular disease is a disease associated with an abnormal condition of the blood vessels, affecting the blood flow to the body.

There are many types of vascular disease associated with vascular constriction, including stroke, peripheral artery disease (PAD), a disease is caused by reduced blood flow to the limbs, abdominal aortic aneurysm (AAA), carotid artery disease (CAD),  arteriovenous malformation (AVM), pulmonary embolism (blood clots) and  deep vein thrombosis (DVT).

According to the statistics, approximately 8.5 million people in the US are living with Peripheral artery disease (PAD), one of the most common types of vascular disease.

There are no single causes of vascular disease. However, diabetes, hyperlipidemia (high levels of fats in the blood, such as cholesterol and triglycerides), smoking, high blood pressure, obesity, physical inactivity are some of most prevalent factors found in patients with the condition.

Some researchers suggested that the rise of aging patients with vascular disease may be correlated to the promotion of high-fat diet over the past few decades in inducing a large population with obesity and Type II diabetes in the US.

Dr. Morteza Mowlaie, the lead scientist wrote, " Significant positive association between left ventricular hypertrophy and plaque score and also a significant positive association between left ventricular hypertrophy with the presence of chest pain was found (p<0.05)"

And, "Association of diabetes mellitus with the presence of chest pain was positive. A positive correlation between hypertension with plaque score was demonstrated too (p<0.05). Also, an inverse association of plaque score with left ventricular ejection fraction was detected too (p<0.05)".

In other words, patients with diabetes are associated with vascular disease, that induces similar symptoms of atherosclerosis such as left ventricular hypertrophy, chest pain, and hypertension in plaque score

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potent ingredient which processes cardioprotection researchers examined the investigate the effect of onion (Allium cepa) peel hydroalcoholic extract (OPE) on rat hypertension induced by high-fructose diet and aorta contractility.

Three groups of rats were given fructose (10% WN/V) in drinking water for 6 weeks but the control group received tap water and hypertensive groups received saline or OPE at 200, 400 and 800 mg kg(-1) daily for last 3 weeks by gavage.

OPE reduces aorta contractions induced by KCl or Phe in a concentration-dependent manner through its vasorelaxant effects.

L-NAME (100 microM), methylene blue (10 microM) and indomethacin (10 microM) Inhibited nitric oxide, cGMP and prostaglandin synthesis associated with a decrease of vasodilation also inhibited by the administration of OPE.

Furthermore, OPE did not change heart rate but reduced hypertension induced by fructose after 3 weeks of the experimental period.

The efficacy of OPE vasorelaxant activity was attributed to the inhibition of hypertension by extract quercetin content, antioxidant activity and inhibiting vascular smooth muscle cells Ca2+ influx associated with the change of vascular diameter.

Taken altogether, onion may be considered a remedy for the promotion of vasorelaxant activity, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Vasorelaxant and hypotensive effects of Allium cepa peel hydroalcoholic extract in rat by Naseri MK1, Arabian M, Badavi M, Ahangarpour A. (PubMed)
(2) Close association of arterial plaques with left ventricular hypertrophy and ejection fraction in hemodialysis patients by Morteza Mowlaie 1 and Hamid Nasri. (PMC)

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