Wednesday, 28 August 2019

Herbal Coltsfoot (Tussilago farfara), the Potent Antibacterial Antibiotic

By Kyle J. Norton

The bacterial infection is the inflammation caused by the multiplication of bacterias after entering the body successfully.

The process of infection can be divided into many stages. However, most bacterias that try to invade the body were killed in the acute phase of infection by the immune system response through the production of the pro-inflammatory cytokines stimulated by the white blood cell macrophages.

According to the statistic provided by the CDC, each year in the U.S., at least 2 million people get an antibiotic-resistant infection, and at least 23,000 people die due to bacterial infectious disease.

Most people do not experience any symptoms until the microbe multiplication to the peak in its’ population.

Acute infection in most cases is recovered with a week or two. However, if the immune function cannot destroy all the bacterias within 3 to 8 weeks, it will compromise, leading to chronic low-grade inflammatory diseases.

Most common and classical symptoms of acute infection are aches, pains, fever, malaise, and nausea.

The chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD), type 2 diabetes.

A most common risk of bacterial infection is a weakened immune system, particularly in the elderly.

The Institute of Medicine (US) Division of Health Promotion and Disease Prevention in examing the risk of infection in elderly, wrote, "The implications of an aging population for health care are being widely discussed but seldom with the understanding that health promotion and disability prevention are workable concepts for people in the “second 50” years of life".

And, "Pneumonia and influenza are among the leading causes of death and morbidity from infection among older people. Safe and effective vaccines to prevent pneumonia and influenza are available and should be universally used in persons over age 50. Nosocomial (institutionally acquired) infections have a major deleterious impact on persons over 50 and require good infection control practices in hospitals and nursing homes".

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of bacterial infection, researchers examined the effect of the flower bud extract of Tussilago farfara on Gram-positive and Gram-negative bacteria.

The study is to compare the antibacterial activity of a silver and gold nanoparticles of sesquiterpenoids from T. farfara flower bud extract and the use of extract alone.

According to the tested analysis, the silver nanoparticles exerted a two- to the four-fold enhancement of the extract comapred to the extract alone in the treatment of both Gram-positive and Gram-negative bacteria.

The solver nanoparticles also showed the highest antibacterial activity against vancomycin-resistant Enterococci Van-A type Enterococcus faecium, comapred to the extract alone.

  Based on the findings, researchers said, " both nanoparticles synthesized with the sesquiterpenoids from T. farfara flower bud extract can be applied as drug delivery vehicles of anticancer or antibacterial agents for future nanomedicine applications.s".

Taken altogether, coltsfoot and silver and gold nanoparticles of sesquiterpenoids from T. farfara flower bud extract may be considered remedies for the treatment of bacterial infection, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Chemical composition and antibacterial activity of Tussilago farfara (L.) essential oil from Quebec, Canada by Boucher MA1, Côté H1, Pichette A1, Ripoll L1, Legault J. (PubMed)
(2) Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities by Lee YJ1, Song K2, Cha SH3, Cho S4, Kim YS5, Park Y. (PubMed)
(3) The Second Fifty Years by Promoting Health and Preventing Disability (1992). (NCBI)

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