Cancer is a group of chronic diseases caused by irregular cell growth in the tissue of a specific organ due to the alternation of cell DNA.
The colon formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colon cancer is relatively very common, slowly growing and progressing cancer.
According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.
In 2019, 101,420 people in the US will be diagnosed with colon cancer.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potential compound for the treatment of colon cancer with no side effect, researchers examined the effects of Withaferin-A, a withanolide derived from the leaf extract of W. somnifera, anti-colon tumor activity.
On human colorectal cancer (HCT116) cells, the phytochemical not only inhibited the proliferation but also the migration of the tested cancer cells in a concentration-dependent manner.
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of colon cancer in vitro and vivo.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity by Choi BY1, Kim BW. (PubMed)
(2) Immunomodulatory effects of Withania somnifera on azoxymethane-induced experimental colon cancer in mice by Muralikrishnan G1, Dinda AK, Shakeel F. (PubMed)
(3) Colorectal cancer outcomes in patients aged over 85 years by O Ng,1 E Watts,2 CA Bull,2 R Morris,3 A Acheson,2 and A Banerjea. (PMC)