Sunday, 18 August 2019

Herbal Ashwagandha, the Potential Anti Colon Cancer Functional Remedy

By Kyle J. Norton

Cancer is a group of chronic diseases caused by irregular cell growth in the tissue of a specific organ due to the alternation of cell DNA.

Colon cancer is a chronic condition characterized by uncontrolled cell growth in the colon tissue.

Most cases of colon cancer start with the alternation of cells DNA in the cells on the surface of the inner lining colon tissue before proliferating into deeper tissues to form a tumor through abnormal cell cycle division.

The colon formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colon cancer is relatively very common, slowly growing and progressing cancer.

According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.

In 2019, 101,420 people in the US will be diagnosed with colon cancer.

Most common symptoms of colon cancer are a persistent change in your bowel habits, including diarrhea or constipation, blood in your stool, persistent abdominal discomforts, such feeling that your bowel doesn't empty completely accompanied by some general symptoms shared by other types of cancer.

The exact causes of colon cancer are unknown. However, out of many risk factors associated with the onset of the disease, aging may have a strong implication involved in cancer, as the most cases of the colon are found in the older population.

Dr. O Ng and colleagues in a joint study led by the University of Nottingham wrote, "The prevalence of colorectal cancer is increasing in the elderly. We examined the treatment and outcomes in our institution of patients aged over 85 years with proven colorectal adenocarcinoma".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potential compound for the treatment of colon cancer with no side effect, researchers examined the effects of Withaferin-A, a withanolide derived from the leaf extract of W. somnifera, anti-colon tumor activity.

On human colorectal cancer (HCT116) cells, the phytochemical not only inhibited the proliferation but also the migration of the tested cancer cells in a concentration-dependent manner.

In other words, Withaferin-A exhibited cells cycle arrest and blocking cancer cell spreading.

Furthermore, administration of withaferin-A attenuated the expression of pro-inflammatory cytokines activated by protein (STAT3) associated with the development and progression of colon cancer. 

On HCT116 cells xenograft tumors and generated in Balb/c nude mice, withaferin-A showed a strong activity in which significant decrease in the volume and weight of tumors, compared to untreated controls.

Based on the finding, researchers said, "The present study suggests that withaferin-A holds the potential to be developed as a small molecule inhibitor of STAT3 for the treatment of HCT116".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of colon cancer in vitro and vivo.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity by Choi BY1, Kim BW. (PubMed)
(2) Immunomodulatory effects of Withania somnifera on azoxymethane-induced experimental colon cancer in mice by Muralikrishnan G1, Dinda AK, Shakeel F. (PubMed)
(3) Colorectal cancer outcomes in patients aged over 85 years by O Ng,1 E Watts,2 CA Bull,2 R Morris,3 A Acheson,2 and A Banerjea. (PMC)

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