Saturday, 10 August 2019

Bromelain, The Natural Prevention and Treatment of Edema

By Kyle J. Norton

Edema is a condition associated with the abnormal accumulation of fluid in certain tissues within the body.

Depending on the affected area or organs, edema can be peripheral edema or ankle edema, and pulmonary edema if the fluid is accumulated in skin ankle and lung respectively.

Traditional Chinese medicine suggested that fluid accumulation is caused by kidney dysfunction in transport the fluid coming from the pancreas to nourish other body tissues and organs.

In other words, kidney deficiency is a major cause of edema. Similar to the aforementioned condition, conventional medicine also suggested that certain kidney disease can induce fluid retention in some parts of the body.

Furthermore, heart failure, cirrhosis of the liver, venous insufficiency are also the most common systemic diseases that cause edema, epidemiologically.

Most common risk factors associated with the risk of edema are mostly involved in the lifestyle and general health factors, including staying in one position (sitting, standing or supine) for too long, increased sodium intake and hormonal changes due to menstruation.

Some women during the course of pregnancy also experience symptoms of edema, particularly under the skin of the leg.

Furthermore, the use of medications such as Estrogen-based medication Non-steroidal anti-inflammatory drugs (NSAIDs), certain diabetes medications and medical equipment such as vasodilators has also been found to increase the risk of fluid retention.

Conventionally, the treatment of edema is totally depending on the causes of the disease. Untreated edema has been associated with the complication of skin infections or ulcerating, leading to, decreased blood circulation and increasing the risk of blood clots in the deep veins of the body.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of edema, researchers examined the Bromelain-loaded katira gum nanoparticles effect on an animal model.

According to the tested results, the Nanoparticles of the optimized batch showed a strong anti-inflammatory activity by employing the carrageenan-induced rat paw edema method in vivo.

In other words, the anti-inflammatory activity of potential was attributed to enhanced absorption owing to reduced particle size and the protection of bromelain from acid proteases.

Moreover, according to the search of the computerized bibliographic databases Medline, EMBASE, Scopus, and CINAHL was performed on March 23, 2015,  researchers found 7 studies used oral bromelain for the treatment of edema.

5/7 randomized controlled trials reported improvement postprocedure with oral bromelain compared to those of arnica,

Taken altogether, oral bromelain may be used for the treatment of edema, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA. (PubMed)
(2) Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles by Bernela M1, Ahuja M2, Thakur R. (PubMed)

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