Thursday, 15 August 2019

Turmeric Protects the arterial Stiffness Against Onset of Cardiovascular Disease In Diabetes

By Kyle J. Norton

Diabetes is a condition characterized by insufficient insulin entering the bloodstream that regulates the glucose.

Type 1 diabetes is associated with the immune system that destroys the producing insulin beta cells in the pancreas.

Types 2 diabetes is characterized by cells in pancreas died off or receptor sites clogged up by fat and cholesterol.

There are no specific causes of type II diabetes. However, obesity, family history, ethnicity, the increase in age, gestation diabetes, polycystic ovary syndrome, and high blood pressure are the most common prevalent factors found in patients with prediabetes and type II diabetes.

Most common symptoms of diabetes are frequent urination, increased thirst, tiredness. In severe cases, patients may also experience symptoms of blurry vision, slow healing of cuts and wounds, tingling, numbness, or pain in the hands or feet and patches of dark skin.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), more than 100 million U.S. adults are living with diabetes or prediabetes.

In 2015, 30.3 million Americans or 9.4 percent of the U.S.population have diabetes.

Conventionally, medications used for the treatment of type 2 diabetes focus on alleviating the symptoms and improving quality of life and slowing down the progression of the disease.

Untreated and unmanageable type 2 diabetes may induce complications of the onset of cardiovascular disease, nerve damage (neuropathy). kidney damage (nephropathy), eye damage (retinopathy). foot damage and kin conditions.

Believe it or not, over 80% of type 2 diabetes diagnosed worldwide are associated with obesity.

WHO  in the differentiation of the genetics risk in diabetes, wrote, "The major environmental risk factors for T2D are obesity (> 120% ideal body weight or a body mass index > 30 k/m2 ) and a sedentary lifestyle (van Dam, 2003; Shaw and Chisholm, 2003). Thus, the tremendous increase in the rates of T2D in recent years has been attributed, primarily, to the dramatic rise in obesity worldwide (Zimmet et al., 2001). It has been estimated that approximately 80% of all new T2D cases are due to obesity (Lean, 2000)".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the complications of diabetes, researchers examined the effect of Curcuma longa on arterial stiffness and endothelial dysfunction in patients with type 2 diabetes mellitus.

A total of 136 patients of type 2 diabetes participated in the randomized controlled trial including 114 completed at least one follow-up visit and data analysis.

According to the tested assays that measure the arterial stiffness parameters and endothelial dysfunction markers at baseline and every month for 3 months, treatment with C. longa produced significant reduction from baseline in carotid-femoral pulse wave velocity and, left brachial-ankle pulse wave velocity associated with arterial stiffness.

Furthermore, aortic augmentation pressure, aortic augmentation index, and aortic augmentation index involved in the risk of cardiovascular disease were also decreased by the administration of C. longa, compared to placebo.

Moreover, after 3 months of C. longa treatment, C. longa significantly decreases arterial stiffness, compared to placebo in type 2 diabetes mellitus patients.

Taken altogether, turmeric may be considered supplements for the prevention and treatment of arterial stiffness in diabetes patients, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: A randomized, double-blind, parallel arm, placebo-controlled trial by Srinivasan A1, Selvarajan S2, Kamalanathan S3, Kadhiravan T4, Prasanna Lakshmi NC5, Adithan S. (PubMed)
(2) Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes by Lekshmi PC1, Arimboor R, Indulekha PS, Menon AN. (PubMed)
(3) Genetics and Diabetes by WHO

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