Thursday, 8 August 2019

Herbal Turmeric Inhibits Risk Factors Associated with Cardiovascular Disease (CVD)



By Kyle J. Norton

Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle.

 Depending on the types of blood vessel damage or blocked, and heart muscle damage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart or stroke caused by reducing oxygen supply to the brain cells.

Coronary artery disease is a condition in most cases associated with an inflammatory cholesterol-containing plaque in the arteries.

Stroke can be caused by reduced blood flow or small blood vessel bleeding, leading to the death of neurons that affect parts of the brain functioning.

Heart failure, a major health problem associated with the reduced function of the heart affects more than 6.5 million Americans, a leading cause of hospitalization in people older than age 65.

According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.

Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.


Although there are many prevalent factors associated with cardiovascular disease including family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes, some researchers suggested the promotion of a high-fat diet over the past few decades induced widespread obesity may be one major condition that causes the onset of CVD.

Dr. Kachur S wrote, " Obesity is increasingly more common in postindustrial societies, and the burden of childhood obesity is increasing. The major effects of obesity on cardiovascular (CV) health are mediated through the risk of metabolic syndrome (insulin resistance, dyslipidemia, and hypertension), such that an absence of these risk factors in obese individuals may not be associated with increased mortality risk".

And, "The negative effects of obesity on CV health manifest as the accelerated progression of atherosclerosis, higher rates of ventricular remodeling and a higher risk of associated diseases, including stroke, myocardial infarction, and heart failure".

In other words, if you are obese, your risk of CVD is substantially higher compared to a non-obese individual.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of cardiovascular disease (CVD), researchers examined the efficacy of curcumin in the inhibition of cardio-risk factors.

According to the results of the comprehensive literature searching the PubMed, Embase, Ovid, Medline and Cochrane Library databases identified 7 randomized controlled trials including 649 patients, administration of turmeric and curcumin significantly reduced the levels of serum low-density lipoprotein cholesterol (LDL-C), and TG and triglycerides (TG) compared to the control group without affecting the levels of high-density lipoprotein cholesterol (HDL-C).

Furthermore, turmeric and curcumin lower the levels of total cholesterol (TC) in patients with metabolic syndrome.

However, turmeric extract may process a greater effect on reducing serum TC levels compared to curcumin.

Most importantly, turmeric and curcumin showed no serious adverse events in all studies.

In other words, turmeric and curcumin inhibited the parameters associated with risk factors of cardiovascular disease with no side effects.

Based on the findings, researchers said, "turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(2) Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double-blinded, randomized, controlled trial by Campbell MS1, Ouyang A1, I M K2, Charnigo RJ3, Westgate PM3, Fleenor BS. (PubMed)
(3) Obesity and cardiovascular diseases by Kachur S1, Lavie CJ2, de Schutter A3, Milani RV2, Ventura HO. (PubMed)

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