Monday, 5 August 2019

Herbal Ashwagandha Destroys Liver Cancer Cells In Vitro

By Kyle J. Norton

Liver formed part of the detoxed organs in the human body is the largest internal organ that filters the blood coming from the digestive tract, before passing them to the rest of the body.

The liver also plays an essential role to produce cholesterol to build a strong cell wall, steroid hormones, and vitamin D and aid the digestive function in food absorption and detoxify toxic chemicals and metabolizes drugs.

Liver disease is a process of reduced function of the liver acutely or gradually.

According to the Canadian Liver Foundation, approximately one in ten Canadians, or more than 3 million people in Canada has some forms of liver disease.  95% of deaths from liver disease are due to chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer, including 25% of obese patients.

Compared to cancer caused by irregular cell growth in specific tissues of an organ, liver cancer precisely is caused by uncontrolled cell growth in the liver tissue that starts in the cells on the surface of the inner lining tissue of the liver.

At the advanced stage, the cancerous cell in the primary liver cancer can travel a distance away to infect other nearby healthy tissue or organ, via blood and fluid circulation, leading to secondary metastasis.

Liver cancer is caused by the alternation of liver cell DNA. Because of lower nerve tissue, most patients in the very early stage of liver cancer are assymptomatic. However, at the advanced stage, patients may experience symptoms upper abdominal pain, general weakness, abdominal swelling, jaundice and white, chalky stools accompanied by general symptoms shared by other types of cancer.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

The 5-year survival rate of 44% of people diagnosed in the early stage of liver cancer only is 31%., comapred to 90% and 100% of colon and breast cancer, respectively.

Some researchers suggested long-term excessive alcohol use has been linked to an increased risk of liver cancer and worse prognosis comapred to other forms of liver cancer

"Liver cancer is the second leading cause of cancer-related deaths worldwide, with hepatitis B and C infections being the main causes".

"Alcohol abuse and non-alcoholic fatty liver disease are other dominant risk factors. Due to improvements in the treatment of hepatitis infections and increased alcohol consumption in some regions, it is likely that alcohol will become a leading cause of liver cancer".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On the finding a potent ingredient for the treatment of liver cancer, researchers investigated the antioxidant and apoptotic inductive effects of Withania somnifera (Ashwagandha) leaf extract ((ASH-WX; 6.25 mg/ml-100 mg/ml)) against a hepatocellular carcinoma cell line (HepG2cells).

According to the tested differentiation, ASH-WX injection demonstrated increased cytotoxicity in HepG2 cells compared to untreated control with IC50 of 5% (approximately 5.0 mg/ml).

ASH-WX also exerted strong antioxidant activities by increasing the levels of Fas-ligand associated with cell death programming and matrixes involved regulating of cancer cell migration, invasion, and metastasis and decreasing the production of pro-inflammatory induced systemic inflammation.

Furthermore, the extracts were also found to interact with cyclin D1, an important regulator of cell cycle progression.

More precisely, ASH-WX induced cell death in HepG2cells was found to increase significant accumulation in the G0/G1 and G2/M phases compared to the control and untreated cells.

In other words, ASH-WX blocked the proliferation through cell cycle arrest.

Based on the results, researchers said, "Ashwagandha could be a powerful antioxidant and a promising anticancer agent against HCC".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of liver cancer, pending to larger sample size and multicenter study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Antioxidant activity and apoptotic induction as mechanisms of action of Withaniasomnifera (Ashwagandha) against a hepatocellular carcinoma cell line by Ahmed W1, Mofed D1, Zekri AR2, El-Sayed N3, Rahouma M4, Sabet S. (PubMed)
(2) Liver cancer caused by alcohol consumption may have a worse prognosis than other forms by Wiley. (Medical Express)

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