Monday, 26 August 2019

Herbal Ashwagandha Inhibits Testosterone Deficiency in Vivo

By Kyle J. Norton

Testosterone is a steroid hormone found in humans produced mostly from the testicles in men and a small amount in women's ovaries.

According to epidemiological studies, treatment for hypogonadism is on the rise, particularly in the population due to natural reduced production of levels of testosterone other than normal aging.

Testosterone production starts to produce significantly during puberty and dip after age 30.

In males, the early onset of reduced production of levels of testosterone is associated with a highly prevalent burden of comorbid medical conditions and polypharmacy complicates, compared to those of normal aging,

Also, low levels of testosterone in males are associated with the early onset of metabolic syndrome in the induction of cardiovascular disease and type 2 diabetes.

Apart from normal aging, low levels of testosterone are found to induce symptoms of decreased sex drive, low energy, weight gain, the risk of depression, and moodiness, loss of hair and thinner bones.

If you are experiencing some of the above symptoms, you may have low levels of testosterone. Please make sure you check with your doctor to rule out the possibility.

Dr. Giagulli VA, in examining the complications of testosterone in men wrote, "Testosterone deficiency syndrome (TDS) induces several negative effects that generally involve different organs such as testis, bone, skeletal muscle, and heart, leading to reduction in testis function, causing osteoporosis, strongly reducing muscle mass, decreasing exercise capacity and strength and facilitating heart failure".

And, " Approximately 25% of patients affected by chronic heart failure (CHF) is characterized by plasma Testosterone (T) levels below normal ranges also related to disease progression".

These results clearly suggested apart from normal aging, males with testosterone deficiency are associated with the complications of many ailments.

Conventionally, testosterone replacement therapy has been found to increase sexual function, lean muscle mass and strength, mood and cognitive function, with a possible reduction in frailty and osteoporosis.

However, Dr. E. Charles Osterberg and colleagues in the examining the benefits and risk of TRT wrote, "The benefits seen with TRT, such as increased libido and energy level, beneficial effects on bone density, strength and muscle as well as cardioprotective effects, have been well-documented. TRT is contraindicated in men with untreated prostate and breast cancer. Men on TRT should be monitored for side-effects such as polycythemia, peripheral edema, cardiac and hepatic dysfunction".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of testosterone deficiency, researchers examined the effect of a methanolic extract of Withania somnifera (L.) Dunal roots on sexual competence in an animal model.

Male rats selected to the study prior to treatment day 3 and 7 of treatment, and day 7, 14 and 30 post-treatment before orally administering 3000 of root extract for 7 days by pairing each male with a receptive female.

Based on the tested differentiation, the root extract showed a significant activity by improving the impairment in libido, and sexual performance, comapred to baseline.

Furthermore, sexual vigor and penile erectile dysfunction in the tested rats were also strongly improved by the administration of root extract in a time-dependent manner.

Most importantly, cessation of treatment of the extract partly reversed this efficacy.

However, the injection of the extract showed an antimasculine side effect that was not attributed to the change of testosterone levels but the promotion of hyperprolactinemic, GABAergic, serotonergic or sedative activities.

Based on the findings, researchers said, "Use of W. somnifera roots may be detrimental to male sexual competence".

Taken altogether, Ashwagandha may be considered a functional herb for the treatment of testosterone deficiency in male, pending to the result of larger sample size and multicenter study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats by Rahmati B1, Ghosian Moghaddam MH2, Khalili M1, Enayati E3, Maleki M2, Rezaeei S. (PubMed)
(2) Effect of Withania somnifera root extract on the sexual behavior of male rats by Ilayperuma I1, Ratnasooriya WD, Weerasooriya TR. (PubMed)
(3) Testosterone deficiency in male: a risk factor for heart failure by Giagulli VA1, Guastamacchia E, De Pergola G, Iacoviello M, Triggiani V. (PubMed)
(4) Testosterone Replacement Therapy and Mortality in Older Men by Hackett GI. (PubMed)
(5) Risks of testosterone replacement therapy in men by E. Charles Osterberg, Aaron M. Bernie, and Ranjith Ramasamy. (PMC)

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