Sunday, 12 November 2017

*****Herbal Therapy: Green Tea, The Best or Worse Renal Disease Functional Food?(Revised Edition)

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the existence of modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Green tea showed to inhibited or exhibited kidney function in toxin elimination in deteriorated renal function in patient with chronic renal disease, studies proposed.

Renal Disease is an impaired function in toxin elimination for more than a specific time as a result of kidney damage or injure.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will be helpful to solve the problem.

In mice fed with a powdered diet containing green tea polyphenolic extract (0.1%) starting 3 days prior to CsA treatment (25 mg/kg, i.g. daily for 3 weeks).showed a decreased renal nuclear DNA-encoded oxidative phosphorylation (OXPHOS) protein ATP synthase-β (AS-β)by 42%, mitochondrial DNA (mtDNA)-encoded OXPHOS protein NADH dehydrogenase-3 (ND3) involved oxidize nutrients for energy conversion by 87%.

Flavanols (polyphenols) are rich phytochemicals isolated from green tea, particularly in the expression in form of most bioactive flavanol EGCG.

Oxidative phosphorylation (OXPHOS) protein ATP synthase-β (AS-β) plays a key role in energy production and regulated the generation of free radicals, and apoptosis through respiratory chain.

Mitochondrial DNA (mtDNA)-encoded OXPHOS protein NADH dehydrogenase-3 (ND3) in reduced risk of gene mutation through oxidative phosphorylation (OXPHOS).

Dr. Rehman H, the lead author said," Green tea polyphenols markedly attenuated CsA-induced renal injury and improved renal function. Together, these results demonstrate that green tea polyphenols attenuate CsA-induced kidney injury, at least in part, through the stimulation of MB".

In support of the efficacy of green tea for treatment of renal disease, the study of F40 rats randomly divided into 4 groups. Group 1 acted as control; group 2 received contrast medium (intravenous iodixanol, 10 mL/kg, as a single dose); group 3 received contrast medium and then green tea extract for 3 days (10 mg/kg/d, intraperitoneal); and group 4 first received green tea and then contrast medium, researchers showed that group treated with green tea had significantly higher overall scores than the control group.

Treatment group also expressed a significant improvement in progression of renal degeneration caused by nephrotoxicity of contrast media. 

Unfortunately, according to the joint study lead by the China Medical University,  inhibited the elimination of indoxyl sulfate (IS) and p-cresyl sulfate (PCS), a highly protein-bound nephro-cardiovascular toxins in CRF rats.

Catechin, is another major chemical constituent isolated from Green tea (GT) and a popular beverage in China.

Indoxyl sulfate(IS), a circulating uremic toxin has found to associate to the development of glomerular sclerosis and interstitial fibrosis.

P-Cresyl sulfate (pCS) is also an uremic toxin generated by intestinal bacteria
which has an implication to worsen outcome of patients with chronic kidney disease and increased cardiovascular burden.

Furthermore, green tea injection of experiment mice also showed a significantly increased the levels of serum creatinine (Cr) and blood urea nitrogen (BUN), an indication of further kidney damage after ingestion of green tea catechin.

Dr. Peng YH, the lead author said, "GT inhibited the elimination of nephro-cardiovascular toxins such as IS and PCS, and deteriorated the renal function in CRF rats".

Taking together, the conflict results of green tea in expression of chronic renal disease may be due to study design, the group sample, the subject selection doses administration,........., therefore patients with renal disease should be consult with specialists before taking.

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(1) Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure by Peng YH1, Sweet DH2, Lin SP1, Yu CP1, Lee Chao PD1, Hou YC1,3,4.(PubMed)
(2) Green tea polyphenols stimulate mitochondrial biogenesis and improve renalfunction after chronic cyclosporin a treatment in rats by Rehman H1, Krishnasamy Y, Haque K, Thurman RG, Lemasters JJ, Schnellmann RG, Zhong Z.(PubMed)
(3) Ameliorative effect of green tea against contrast-induced renal tubular cell injury by Nasri H, Hajian S, Ahmadi A, Baradaran A, Kohi G, Nasri P, Rafieian-Kopaei M1.(PubMed)

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