Kyle J. Norton
Beet or Beetroot, may have a potential effect in ameliorated abnormal function of white blood cells such as neutrophils in reduced risk and treatment of inflammatory bowel disease.
Inflammation is a natural process of immune defense to remove injurious agents, cells and tissues from the body.
Inflammatory bowel disease is the boarder term of conditions characterized by chronic inflammation of intestines, including ulcerative colitis and Crohn disease.
Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Poznan University of Medial Science, beetroot (Beta vulgaris var. rubra) products and their major component betanin exhibited antioxidant activities against abnormal neutrophils in modulated reactive oxygen species (ROS) production and DNA damage, in healthy subjects.
The efficacy of betanin in reduced reactive oxygen species (ROS) expression is the result of exerting antioxidant free radical scavenging and neutralizing activities by slowed down or prevented initiation of free radical chain reaction.
Additionally, betanin, as a major phytochemical also ameliorated the elevated ROS expression in promoted oxidative stress which was found to have a strong implication to cause cellular DNA damage. Some researchers suggested that betanin reduced risk of cellular DNA damage.probably through inter influenced the pro apoptotic caspase-3 in the action of release of ROS and apoptotic cell death.
In case of anti inflammation, both betaine and baicalein also found to demonstrate a magnificent impact in regulation of the pro inflammatory cytokins such as IL-1β, PGE2, and TNF-α in NF-ĸB activation beside activities in inhibited expression of ROS.
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Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W1.(PubMed)
(2) Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine by Kim DH1, Sung B1, Chung HY1, Kim ND1.(PubMed)
(3) In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp by Vigsnæs LK1, Holck J, Meyer AS, Licht TR.(PubMed)
(4) Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and NF-κB-dependent pathways by Fan GW1, Zhang Y, Jiang X, Zhu Y, Wang B, Su L, Cao W, Zhang H, Gao X.(PubMed)