Friday, 24 November 2017

Food Therapy: Dried Peas, The Best in Prediction, Prevention and Treatment of Liver Diseases

Kyle J. Norton

Intake of dried peas daily and regularly may associate to reduce risk of liver diseases, scientists at some respectable institute studies suggested.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

Liver diseases are set of medical condition, ranging from Cirrhosis, or scarring of the liver. Inflammation (hepatitis) from infectious (hepatitis B, hepatitis C) to benign and malignant tumors.

In a hydroalcoholic extract (PE) of pea (Pisum sativum L.) by-product was investigate for its hepatoprotective against CCl4-induced oxidative stress and hepatic damage in rats, researchers at the Cairo University after taking account of existed con founders, found that
1. The by product displayed a significant effect in reduced ROS expression in induction of liver damamge through enhance antioxidant activity.
2. N-butanol fraction isolated from hydroalcoholic extract (PE) demonstrated stronger liver protective effect in compare to other petrochemicals.

The findings demonstrated that  hydroalcoholic extract (PE) of pea by-product can be utilized to obtain high value added products for therapeutic use in ameliorated risk and treatment liver diseases.

People who have a history of liver problems may consider to add portions of dried peas into their diet for preventive measure.

Further analysis the study also indicated that the by product also exert a significant antioxidant activity against the free radical expression and intimated a chain of harmful domino effect in inducing oxidative stress in the liver, which has been considered as a conjoint pathological mechanism.

Dr. Li S, the lead author at the University of Hong Kong, said, "(there is no surprise that) various factors that cause oxidative stress in liver and effects of antioxidants in the prevention and treatment of liver diseases ......".

In deed, application of antioxidants in animal studies has revealed a significant effect in prevented and cured liver diseases involving oxidative stress.

In the concerns of types of phytochemicals may have contributed to the hepatoprotective effect from peas, researchers at the Kyoto Pharmaceutical University launched an investigation to isolate some suspected chemical compounds from the young seedpods of garden peas, showed that
1. Not all chemicals isolated exerted similar in liver protection
2. Some compounds are more effective in compared to others

Further differentiation, researchers suggested, out of many components, Quercetin 3-sophorotrioside, was found to show clinical significantly protective effects on liver injury induced by D-galactosamine and lipopolysaccharide and by carbon tetrachloride in mice study, in compared those of ionone glucoside, pisumionoside, a phenethyl glycoside, sayaendoside, and two acylated flavonol oligoglycosides, pisumflavonosides.

More importantly, in support of the above analysis, researchers at the Changhai Hospital also conducted a study to evaluate the alpha-fetoprotein reactive to Pisum sativum agglutinin levels (AFP-R-PSA) of 24 patients with hepatocellular carcinoma (HCC) and 54 patients with benign liver diseases (BLD) showed that
1. Alpha-fetoprotein levels were higher in patient with liver cancer and suggested that the measured AFP-R-PSA level above 25% may be considered as a value in highly suggestive of HCC with a positive prediction value of 98% accuracy.
2. According to the sensitivity of the test, value of 74% in serum AFP level below 400 micrograms/L was found in 31 patients with a tumor size less than 5cm.
3. In the combined test of (AFP-R-PSA), the detection rate of small HCC was increased from 32% to 87%.
It is amazing that Pisum sativum lectin or agglutinin (PSA), another chemical compound isolated from peas also have a strong effect in prediction of the development and size benign liver diseases (BLD) and liver cancers.

With all information collected from the data of medical literature, we believed,  the efficacy of dried peas in reduced risk and treatment of liver diseases may be attributed to various unknown mechanisms, that are waiting to discover.

These effectiveness also does not assure that patients with liver disease can be cured by adding a significant portions of pea into their diet, because of the small sample sizes and only ingredients isolated from peas were used to perform these testing in all studies. 

But taking together, it is safe to conclude that intake of dried peas may have a profound and positive potency in induced hetapoprotective against liver diseases.

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Bioassay-guided fractionation of a hepatoprotective and antioxidant extract of peaby-product by Seida AA1, El Tanbouly ND, Islam WT, Eid HH, El Maraghy SA, El Senousy AS.(PubMed)
(2) Medicinal foodstuffs. XXV. Hepatoprotective principle and structures of ionone glucoside, phenethyl glycoside, and flavonol oligoglycosides from young seedpods of garden peas, Pisum sativum L by Murakami T1, Kohno K, Ninomiya K, Matsuda H, Yoshikawa M.(PubMed)
(3) Alpha-fetoprotein reaction to Pisum sativum agglutinin in differentiation of benign liver diseases from hepatocellular carcinoma by Yin ZF1, Tu ZX, Cui ZF, Wu MC.(PubMed)
(4) The Role of Oxidative Stress and Antioxidants in Liver Diseases by Li S1, Tan HY2, Wang N3, Zhang ZJ4, Lao L5, Wong CW6, Feng Y7.(PubMed)

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