Saturday, 4 November 2017

Food Therapy: Coffee Intake in Risk of Pancreatic Cancers? The Contradictory Results

Kyle J. Norton, Master of Nutrients


Epidemiological studies do not agreed that coffee consumed regularly and daily is associated to decreased risk of pancreatic cancer, a study by the Fudan University suggested.

Pancreatic cancer is a medical condition of cell growth irregularly and disorderly in the pancreas. At the late stage, the cancer cells may travel a distant away from the original site to other tissues and organs.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review literature published on PubMed and EmBase to determine the risk of pancreatic cancer associated with a 1 cup/d increment in coffee consumption, 14 studies met the inclusion criteria with 671,080 individuals (1496 cancer events) with an average follow-up of 14.9 years, researchers found that in compared to non coffee drinkers, coffee drinkers enjoyed a relative odd risk ratio of 0.82 and 0.68 in compared regular high drinkers and low to moderate coffee drinkers,

This result confirmed  the linearly negative risk  associated between coffee intake and pancreatic cancer. Risk of PC is reduced further for additional intake.

Constrastively, in the evaluated the relationship of coffee ingestion and pancreatic cancer risk by searching prospective cohort studies and explicit document in the PubMed database before November 2015. researchers expressed that   risk pancreatic cancer is increased, by 1% for additional cup of coffee intake, regardless numbers of cups of coffee intake daily.

Dr, Nie K, The lead author said, "The summary relative risk (RR) of pancreatic cancer and coffee intake of the highest compared with lowest category was 0.99 (95% CI=0.81-1.21), with statistically moderate heterogeneity (I2=47.9%, P=0.008)".

The risk of pancreatic cancer in coffee drinker remain constant even after taking account of other factors such as geographic areas, sex of participants, number of cases, follow-up years, ....

Additionally, in the evaluated coffee intake and risk of pancreatic cancer of a review of 4 155 256 person-years of follow-up, 1541 incident first primary pancreatic cancers incidence, scientists strongly insisted that risk estimates for coffee drinking were not statistically significant; compared with never drinkers of coffee, regardless to numbers of coffee intake.

Dr. Dr.Guertin KA, the lead researcher. said, "In a prospective study of coffee intake with the largest number of pancreatic cancer cases to date, we did not observe an association between total, caffeinated, or decaffeinated coffee intake and pancreatic cancer".


Taking together, There are some contradicted results in expression of coffee intake and risk of pancreatic cancer, but the findings suggested that coffee intake is associated to insignificant risk of pancreatic cancer incidence. Further studies are warranted.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee drinking and pancreatic cancer risk: a meta-analysis of cohort studies by Dong J1, Zou J, Yu XF.(PubMed)
(2) Coffee intake and risk of pancreatic cancer: an updated meta-analysis of prospective studies by Nie K1, Xing Z, Huang W, Wang W, Liu W.(PubMed)
(3) Intake of coffee, decaffeinated coffee, or tea does not affect risk for pancreatic cancer: results from the European Prospective Investigation into Nutrition and Cancer Study by Bhoo-Pathy N1, Uiterwaal CS, Dik VK, Jeurnink SM, Bech BH, Overvad K, Halkjær J, Tjønneland A, Boutron-Ruault MC, Fagherazzi G, Racine A, Katzke VA, Li K, Boeing H, Floegel A, Androulidaki A, Bamia C, Trichopoulou A, Masala G, Panico S, Crosignani P, Tumino R, Vineis P, Peeters PH, Gavrilyuk O, Skeie G, Weiderpass E, Duell EJ, Arguelles M, Molina-Montes E, Navarro C, Ardanaz E, Dorronsoro M, Lindkvist B, Wallström P, Sund M, Ye W, Khaw KT, Wareham N, Key TJ, Travis RC, Duarte-Salles T, Freisling H, Licaj I, Gallo V, Michaud DS, Riboli E, Bueno-De-Mesquita HB.(PubMed)

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