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Yoga intervention may have a potential effect in regulated gene expression in some related diseases, researchers at the University of Oslo suggested.
Mutated gene expression included many factors, most common factors are
1. Gene mutation inherited from gene defect parents
2. Gene expression may be altered in the process of regulatory sequences and the transcription factors, cofactors, chromatin regulators and noncoding RNAs
3. Gene mutation is a natural process to protect existence of human beings. Unfortunately, the process in some cases may produce certain subgroups who are vulnerable and susceptible to some diseases.
Biologically, unnatural causes of gene expression due to prolonged exposure to certain harmful agents such as environment toxins, long term used of single or multi ingredients medication,... may also induce genetic change to the negative ways.
Diseases caused by mutated gene expression, include cancer, autoimmunity, neurological disorders, diabetes...
Yoga, the ancient technique for harmonized external and internal body well beings, through breath control, meditation, bodily movement and gesture..... has been best known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.
In the study to investigate whether the effects on the mind-body system in increased wellness and supported the healing process from diseases, researchers found that yoga intervention not only improved psychological and physiological functioning but also may have regulated effect in gene expression profiling in circulating immune cells, particularly in the molecular level.
Indeed, yoga can improve immunity through a sequence of post in strengthening the body and relaxing the mind. Some believed that by strengthening the body and relaxing the mind, yoga acted as regulators of gene expression in innate and adaptive cell of immune system, through noncoding RNAs, thus reducing risk of inflammatory and auto immune diseases.
In further exploration of the yoga effect in gene expression in the molecular level, researcher at the joint study led by the Coventry University, postulated that mind-body interventions (MBIs) showed a significantly reverse expression of genes involved in inflammatory reactions induced by stress.
Yoga, a mind-body practice of physical poses, controlled breathing, and meditation or relaxation has been best known to reduce implication of stress in increased production of inflammatory cytokins in gene expression, including interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha), thus reducing risk of inflammatory diseases.
And after examined the changes in gene expression that occur after MBIs and to explore how these molecular changes are related to health, through searching the data base of published literature from PubMed throughout September 2016, researcher indicated that over all studies selected indicated an association of gene changes in yoga intervention was a result downregulation of nuclear factor kappa B pathway.
Furthermore, MBI practices may lead to a reduced risk of inflammation-related diseases, through the reduced effects of chronic stress on gene expression.
Most interestingly, in the assessed possible rapid changes in global gene expression profiles in the peripheral blood mononuclear cells (PBMCs) in healthy people practiced either a comprehensive yoga program or a control regimen, researchers found that SK&P program has a more rapid and significantly greater effect on gene expression in PBMCs compared with the control regimen.
Peripheral blood mononuclear cell (PBMC) include lymphocytes (T cells, B cells, NK cells) ,monocytes and granulocytes which play an important role in improved immune system cellular function in fighting against infection and inflammation, enhanced tissue regeneration, restored function due to injure, .....
Truly, the impact of yoga in protection of gene expression of immune system may involve a complexity of simple gene regulatory networks (GRNs), including the gene expression in PBMCs and inflammatory cytokins
Taking altogether, Yoga intervention and related practices may have a profound effect in gene expression alterations through a complex networks of simple gene regulation in the immune system.
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(1) Regulation of gene expression by yoga, meditation and related practices: a review of recent studies by Saatcioglu F1(PubMed)
(2) Rapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program by Qu S1, Olafsrud SM, Meza-Zepeda LA, Saatcioglu F.(PubMed)
(3) What Is the Molecular Signature of Mind-Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices by Buric I1,2, Farias M1, Jong J1, Mee C3, Brazil IA1,2,4,5.(PubMed)