Food therapy: Coffee Intake in Reduced Risk of Chronic Hepatitis

By Kyle J. Norton


Good news for coffee lovers, intake of coffee daily and regularly showed to express a positive effect in reduced risk and progression of chronic hepatitis. a renowned institute joint study suggested.

Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Chronic hepatitis is a condition of liver inflammation caused by hepatitis B and C viruses and certain drugs, lasting at least 6 months.

According to the joint study lead by the Michael E. DeBakey VA Medical Center and Baylor College of Medicine, intake of coffee and coffee caffeine modestly may have profound effect in protection against advanced hepatic fibrosis caused by viral infection in men with chronic HCV infection.

In the study of 910 patients with chronic HCV infection, 98% male and 38% with advanced hepatic fibrosis with daily intake of caffeinated coffee higher among controls than patients with advanced fibrosis, researchers filed the following results
1. Coffee was one of most caffeine injected by participants in the control group.
2. Consumed 100 mg or more of caffeine daily from all sources was found in more participants on higher percentage of controls (66.0%) group in compared to patients with advanced fibrosis group.
3. Daily intake of 100 mg or more of caffeine also expressed a significant hepatoprotective effects in controls.

These finding evidences suggested that caffeine, a major chemical compound may play an important role in reduced risk of chronic hepatitis substantially in compared to non caffeinnate drinkers..

In further support of coffee intake in attenuated risk of the progression of chronic liver diseases (NASH, viral hepatitis, liver cirrhosis, hepatocelullar carcinoma)..., Dr Szántová M and colleagues in the review of in experimental, clinical and large population studies found that coffee consumption showed a significant hepoprotective activities through  decreasing mortality, improved antioxidant, antifibrotic, insulinsensitizing and anticarcinogenic expression. And the key protective components involved in this protection may include Chlorogenic acids, diterpens (cafestol, kahweol), caffeine, polyfenols and melanoidins.

More importantly, Dr. Szántová M,, the lead author said,"(The liver protective activity of coffee against chronic hepatitis may be attributed to action in)modulation of genetic expression of key enzymes of fatty acid synthesis, modulation of mRNA included in autophagia, reduction of stress of endoplasmatic reticulum together with decrease of proinflammatory cytokines and decrease of fibrogenesis are main mechanisms" and " Coffee is non-pharmacological tool of primary and secondary prevention of chronic liver diseases".

Promissingly, the University of Naples "Federico II, in the study of the relationship between coffee and liver health, indicated that coffee consumption not only showed a inversely associated with the activity of liver enzymes in subjects at risk, including heavy drinkers but also inhibited hepatic steatosis and fibrosis, ...cirrhosis and the risk of hepatocellular carcinoma".

Taking together, there is no doubt that intake of coffee daily and regularly regardless to numbers of cup, expressed a significant effect in reduced risk and treatment of chronic liver disease, particular in chronic hepatitis.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C by Khalaf N1, White D1, Kanwal F1, Ramsey D1, Mittal S1, Tavakoli-Tabasi S2, Kuzniarek J3, El-Serag HB4.(PubMed)
(2) [Coffee as hepatoprotective factor].[Article in Czech] by Szántová M, Ďurkovičová Z.(PubMed)
(3) Coffee and liver health by Morisco F1, Lembo V, Mazzone G, Camera S, Caporaso N.(PubMed)