Tuesday, 28 November 2017

Food therapy: Dried Peas, the Best and Potent Anti inflammatory Agent

Kyle J. Norton


Intake of dried peas daily and regularly may reduce risk and treatment of chronic inflammatory diseases, some institute studies suggested.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

Inflammation is a natural process of the immune system to heal body damage and injure caused by invasion of foreign substances, including bacteria and virus.

In the study to evaluate the preventive effects of two pea (Pisum sativum) seed albumin extracts, either in the presence (pea seed extract [PSE]) or absence (albumin fraction from PSE [AF-PSE]) of soluble polysaccharides, in the dextran sodium sulfate (DSS) induced colitis in mice assigned to five groups: one noncolitic and four colitic, researchers found that
1. All treatment groups displayed a significantly intestinal anti-inflammatory effect, observed by reduced microscopic histological damage in comparison with nontreated mice
2. Peas extract treatment group was found to ameliorate pro inflammatory markers through regulating the colonic mRNA expression.
3. The chemical isolated also improve the proteins expression involved in maintaining the epithelial barrier function in prevent the passage of foreign antigens, microorganisms and toxins.

In other words, pea (Pisum sativum) seed albumin extracts not only inhibited auto immune response in expression of RNA in transmitting information to proteins involved production of pro inflammatory cytokins but also strengthened colonic cells in prevented permeation of noxious agents, 

Further differentiation, researchers also indicated that application of peas extract also improved gut bacterial function, partially or totally  in compared to healthy mice.

The findings may provide people with high risk chronic inflammatory diseases to  reconsider adding a portion of dried peas into their daily diet for preventive measure.

Truly, peas extract not only have a profound effect in reduced symptoms implicated by inflammatory cytokins but also hold an important key to restore the gut bacteria partially and totally, particularly in patient with colitis.

Other researchers, in a murine model. study to investigate the effect of enzymatic protein hydrolysates isolated from yellow pea seed in risk of inflammation showed that
1. the isolated protein demonstrated a significant activity in inhibited the secretion of pro-inflammatory cytokines, TNF-α- and IL-6, up to 35 and 80%, respectively
2. Peas proetein also expressed a strong effect in regulate up-regulation of IL-6 secretion by small intestine epithelial cells (IEC), in reduced risk inflammation caused by B-cell terminal differentiation to IgA-secreting cells.

TNF-α, tumor necrosis factor tumor necrosis factor is a protein with function in regulated the production of inflammatory cytokins in the acute phase of invasion by foreign substances.

Interleukin 6 (IL-6) is an interleukin has a duo functions in activated either pro-inflammatory cytokine or anti-inflammatory myokine.

With the amazingly collective information Dr. Ndiaye F, the lead authors suggested, "the resulted peptides could be used as an alternative therapy for the prevention of inflammatory-related diseases".


More importantly in the study to evaluate the anti-inflammatory and platelet aggregation effects of three medicinal plants of Pakistan. Methanolic extract of garden pea, researchers after considering to other con founders postulated that
1.  Methanol extract of Desi chickpea inhibited arachidonic acid (AA) induced platelet aggregation (IC50 value = AA = 46 microg/mL) 
2. In compared to 2 other plants, garden pea (Pisum sativum) demonstrated a strongest effect in inhibited PGE2 by 92% in comparison with untreated control wells), Desi chickpea by 87% and Kabuli chickpea extracts by 65%.

Prostaglandin E2 (PGE-2) is another pro inflammatory protein with function in response to infection or inflammation produced by blood vessel walls.

Arachidonic acid is a polyunsaturated omega-6 fatty acid with function in mediated or modulated inflammatory reactions.

Since all ingredients displayed a significant activity in protect the natural body defense mechanism for the removal of injurious agents, necrosed cells and tissues from the body without elevating the inflammatory production, Dr. Zia-ul-Haq M, the lead author said, " Garden pea, Desi chickpea and Kabuli chickpea could be useful as natural antithrombotic anti-inflammatory materials".

The information collected from above studies, demonstrated that the specific factions or ingredients isolated from peas may have a significant effect in reduced expression of pro inflammatory substances with out taking account of complete picture of the whole food.

Therefore, intake of a large portion dried peas daily of patients with chronic inflammatory diseases does not automatically mean a completely recovered from such illness.

In fact, most studies in the article have used either a small sample size or in a early stage of animal experiment, thus clinical studies are necessary to re confirm these validation.

However, it is safe to suggest that intake of dried peas may have a strong implication in ameliorated risk of inflammation without altering the function of immune modulating effect.




Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis by Utrilla MP1, Peinado MJ, Ruiz R, Rodriguez-Nogales A, Algieri F, Rodriguez-Cabezas ME, Clemente A, Galvez J, Rubio LA.(PubMed)
(2) Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds by Ndiaye F1, Vuong T, Duarte J, Aluko RE, Matar C.(PubMed)
(3) Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. by Zia-ul-Haq M1, Khan BA, Landa P, Kutil Z, Ahmed S, Qayum M, Ahmad S.(PubMed)




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