Wednesday, 8 January 2014

Phytochemical Allyl isothiocyanate and Brain Cancer

  Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

Brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originating is not very common. Most primary tumors are caused by abnormal cells growth that surround and support neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in US are diagnosed with a brain tumor each year alone.

Allyl isothiocyanate  and Brain Cancer

Allyl isothiocyanate (AITC) found in various cruciferous vegetables, beside has shown the inhibition  of leukemia HL-60, bladder cancer UM-UC-3 and colon cancer HT-29 cells in vitro, it also significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner. Allyl isothiocyanate (AITC) may be another potential source of anti-human brain malignant glioma drug. Other study insisted that intake of Allyl isothiocyanate (AITC) may reduce the risk of cancer but  AITC at high-dose levels also exhibit a low degree of cytotoxicity and genotoxicity, but unlikely in humans exposed to dietary levels of AITC.

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(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC.(PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)