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Wednesday, 8 January 2014

Phytochemical Allicin and anti bacterial activity

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.

The Benefits
Garlic has been used as foods and medicine throughout human history. Allicin, major constituent of garlic in the test for the antimicrobial activity on oral pathogens associated with dental caries and periodontitis, showed an effectiveness against all types of bacteria, including Streptococcus mutans, S. sobrinus, and Actinomyces oris. Other in the study of Streptolysin O (SLO), a potent cytolytic toxin produced by almost all strains of group A streptococci, found that  allicin likely inhibits the SLO by binding to the cysteine residue in the binding site and suggested that allicin and allicin may be a potential alternative drug against streptococcal diseases.



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References
(1) Garlic allicin as a potential agent for controlling oral pathogens by Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D.(PubMed)
(2) Inhibition of streptolysin O by allicin - an active component of garlic by Arzanlou M, Bohlooli S.(PubMed)