Beside the main ingredient andrographolides, giving the plant a bitter taste, other ingredients includediterpene lactones, such as: neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
Administration of containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae) PHF found to be pepatoprotective effect by significantly inhibited paracetamol, CCl(4) and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH with little side effect, according to the study. Other in the study to evaluate the hepatoprotective effect of Andrographis lineata (Acanthaceae) extracts in carbon tetrachloride-induced liver injury in rats, showed that the extracts exhibited hepatoprotective action and may be be considered to be used as a hepatoprotective agent. Also the chemical constituent andrographolide (AN) found in Andrographis, significantly restores serum glutamate oxalacetate transaminase and serum glutamate pyruvate transaminase level.
The Side effects
Dry leaf powder of A. paniculata increases the risk accumulating of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate, thus reducing the risk of fertility.
2. People with gallbladder disease may want to consult with their doctor before using because of the herb stimulating gallbladder contraction effect.
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(1) Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.