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Wednesday, 1 January 2014

Food therapy - Strawberries and Neuroprotective effects

Strawberries
Strawberries is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with suitable climate for commercial profits and for health benefits.
Neuroprotective effects is defined as an event that protects the central nervous system (CNS) by relatively preserving of neuronal structure and/or function.
Nutrients and Chemicals constituents
1. Carbohydrate
2. Dietary fiber
3. Omega 3 fatty acid
4. Calcium
5. Iron
6. Magnesium
7. Phosphorus
8. Potassium
9. Sodium
10. Zinc
11. Copper
12. Manganese
13. Selenium
14. Vitamin C
15. Thiamin
16. Niacin
17. Pantothenic acid
18. Vitamin B-6
19. Folate
20. Vitamin B-12
21. Vitamin A
22. Vitamin E
23. Vitamin K
24. Etc. 
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
The benefits
Many studies has been oncarrying by scientists to explore the effective agent of which has a potential to prevent or slow disease progression and secondary injuries by halting or at least slowing the loss of neurons. In spite of nitochondrial oxidative stress (MOS)  as a major factor in the underlying pathology of many neurodegenerative diseases, chemical constituent anthocyanins suppress MOS-induced apoptosis by preserving mitochondrial GSH and inhibiting cardiolipin oxidation and mitochondrial fragmentation. Also in the the study of Berry fruit supplementation, polyphenolic compounds found in berry fruits, such as blueberries and strawberries, may exert their beneficial effects either through their ability to lower oxidative stress and inflammation or directly by altering the signaling involved in neuronal communication, calcium buffering ability, neuroprotective stress shock proteins, plasticity, aubMed)nd stress signaling pathways. Dr. Richardson JS. indicated that pharmacological agents that protect damaged neurons are not ready yet for widespread clinical use, neuron damaging oxidative stress can be kept in check by insuring adequate dietary sources of antioxidants with little or no scientific evidence, but the consumption of high antioxidant foods, such as blueberries and strawberries, is appealing to most people regardless of any neuroprotective potential.
The Side effects 
1. Some people may be experience anaphylactoid reaction to the consumption of strawberries
2. Oxalation
Oxalates in high concentration can cause problem for people with kidney diseases.
3. Etc. 
 

Reference
(1) The strawberry: composition, nutritional quality, and impact on human health. by Giampieri F, Tulipani S, Alvarez-Suarez JM, Quiles JL, Mezzetti B, Battino M.(PubMed)
(2) Phenolic Composition of Strawberry Genotypes at Different Maturation Stages(ACS Publication)
(3) The Promise of Neuroprotective Agents in Parkinson’s Disease  by Stacey E. Seidl and Judith A. Potashkin(Frontiers in Neurology)
(4) Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress. by Kelsey N, Hulick W, Winter A, Ross E, Linseman D.(PubMed)
(5) Neuroprotective agents. by Richardson JS.(PubMed
(6) Berry fruit supplementation and the aging brain. by Shukitt-Hale B, Lau FC, Joseph JA.(PubMed)