Saturday, 4 January 2014

Food therapy - Black beans (Phaseolus) and Gastric cancer

Black bean is a Small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongs to the family Fabaceae and can bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Gastric Cancer is defined as a condition of the abnormal proliferation of cells in the Gastrointestinal Tract.

Nutrients and Chemicals constituents a. Nutrients
1. Carbohydrate
2. Dietary fiber
3. Protein
4. Fat
5. Vitamin A
6. Vitamin B
7. Folate
8. Vitamin C
9. Calcium
10. Magnesium
11. Manganese
12. Phosphorus
13. Molybdenum
14. Iron
10. Etc.
b. Chemicals constituents
Infection with Helicobacter pylori leads to gastritis, peptic ulcers and gastric cancer. The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols  and malvidin.

The benefits
Anthocyanins, the major chemical compounds of black soybean not only decrease H. pylori-induced ROS enhancement, but also inhibited phosphorylation of mitogen-activated protein kinases, translocation of nuclear factor-kappa B and Iκβα degradationnd H. pylori-induced inducible nitric oxide synthases and cyclooxygenase-2 mRNA expression and IL-8 production by 45.8%. On the other hand, in the study by Dr, Zou Y, and Dr.  Chang SK. indicated that black soybean extract inhibited AGS cell growth in a dose-dependent manner with an IC(50) of 3.69 mg/m and suggested that black soybean extract could be used as an apoptosis inducer in AGS cells and a natural chemopreventive agent in the treatment of human gastric cancer.

The Side effect
1. Purines
Black beans contain purines, excessive intake of these substances can cause the accumulation of uric acid, leading to"gout" and kidney stones.
2. Etc.
References (1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Anthocyanins from black soybean inhibit Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells.

Kim JM, Kim KM, Park EH, Seo JH, Song JY, Shin SC, Kang HL, Lee WK, Cho MJ, Rhee KH, Youn HS, Baik SC.(PubMed)
(3) Effect of black soybean extract on the suppression of the proliferation of human AGS gastric cancer cells via the induction of apoptosis. by Zou Y, Chang SK.(PubMed)