Dithiolthiones, the bioactive compound found abundantly in the cruciferous vegetables may have a potential effect on reducing the risk of neurodegenerative disease, some scientists found.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
A neurodegenerative disease is a group of conditions which primarily affect the neurons in the brain, including Parkinson's disease (PD) and Alzheimer's disease.
In several in vitro and in vivo studies isothiocyanate sulforaphane, derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, has demonstrated neuroprotective effects.
The efficacy was attributed to the activity of sulforaphane in activating the Nrf2/ARE pathway in modulating the expression of oxidative stress.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Sulforaphane alleviates scopolamine-induced memory impairment in mice by Lee S1, Kim J1, Seo SG2, Choi BR3, Han JS3, Lee KW4, Kim J5. (PubMed)
(2) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases byTarozzi A1, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P.(PubMed)
(3) Neuroprotective effect of sulforaphane in a 6-hydroxydopamine-lesioned mouse model of Parkinson's disease byMorroni F1, Tarozzi A, Sita G, Bolondi C, Zolezzi Moraga JM, Cantelli-Forti G, Hrelia P.(PubMed)
(4) Series Introduction: Neurodegeneration: What is it and where are we?by Serge Przedborski,1,2,3 Miquel Vila,1 and Vernice Jackson-Lewis. (PMC)