Herb Arnica may be the next target of the pharmaceutical companies to identify a single ingredient medicine for the treatment of colon cancer, some scientists suggested.
Colon cancer is a slow and predictable condition characterized by irregular cell growth on the colon tissue.
The cause of colon cancer is a result of the alternation of DNA of the cells in the colon.
Most cases of colon cancer start at the cells on the surface of the inner lining of the colon tissue. At this stage, the tumor is very small and does not cause any symptoms.
However, at the later stage, colon cancer may cause symptoms of a change of bowel habits, severe rectal bleeding or blood in your stool and persistently abdominal pain.
If you experience some of the above symptoms that last more than 4 weeks, please check with your doctor to rule out the possibility of colon cancer.
According to the statistic, the 5-year survival rate of people with localized stage colorectal cancer is 90% and only 39% of patients are diagnosed at this early stage.
Researchers do not know why people with the same health condition, family history and diet pattern, some are susceptible to colon cells DNA alternation while others do not.
Out of a number of risk factors, genetic preposition has been under intensifying studies by many scientists.
Dr.Glaser EM in a finding the genetic mutation associated with the risk colon cancer said, "Colorectal cancer is one of the most common malignancies in the United States. Although both genetic and environmental factors play a role in colorectal tumorigenesis" and "single genes that confer a susceptibility to familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). Because these genes are inherited in an autosomal dominant fashion, offspring of carriers have a 50% chance of inheriting the gene mutation and its associated risk".
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.
Besides containing contain helenalin as it main ingredient used as anti-inflammatory agent in herbal medicine, herbal Arnica also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.
In the concerns of the aberrant crypt foci (ACF) and colon-rectal mucosal epithelial cell proliferation in patients with colon cancer, researchers at the University of São Paulo examine the anti-colon cancer of chemical compound isolated from the Lychnophora ericoides Mart. (Brazilian herbal arnica).
* The groups G1 to G4 were given 4 injections of the carcinogen 1,2-dimethylhydrazine (DMH).
* The G2 group received Lychnophora ericoides (LE) extracts for 6 wks.
* The groups G3 and G4 received LE for 4 wk and 2 wk, respectively, at the postinitiation and initiation phases of colonic carcinogenesis.
* The group G5 was the control.
* Groups G1 demonstrated an increase of the number of aberrant crypt foci (ACF) and cancer cells proliferation induced by DMH.
Application of the maximum half-life concentration of 1.0 microM exerted the most cytotoxic effect against COLO 320.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) The protective role of Lychnophora ericoides Mart. (Brazilian arnica) in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis by Fernandes CR, Turatti A, Gouvea DR, Gobbo-Neto L, Diniz A, Ribeiro-Silva A, Lopes NP, Garcia SB.(PubMed)
(2) Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines by Woerdenbag HJ, Merfort I, Passreiter CM, Schmidt TJ, Willuhn G, van Uden W, Pras N, Kampinga HH, Konings AW.(PubMed)
(3) Inherited predisposition to colon cancer by Glaser EM. (PubMed)