Sunday, 23 December 2018

Aloe Vera Inhibited Symptoms and Progression of Polycystic Ovarian Syndrome With No Side Effects, According to Studies

By Kyle J. Norton

Scientists may have found a natural whole herb for the treatment of polycystic ovarian syndrome (PCOs) with no side effects some studies suggested.

The polycystic ovarian syndrome is an endocrinologic disease caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries

PCOs induced enlarged ovaries can facilitate the onset of certain complications, including hormone imbalance( excessive androgen), male pattern hair development, acne, irregular period or absence of period, weight gain and infertility.

According to the statistic, polycystic ovary syndrome (PCOs) is a health condition, affecting 1 in 10 women of childbearing age. in the Western world.

The exact causes of polycystic ovary syndrome (PCOs)  are unknown, However, according to epidemiological studies, high levels of androgens. and insulin is the 2 characteristics of women with the syndrome.

Women who have the onset of polycystic ovary syndrome (PCOs)  also experience additional health problems, including diabetes, high blood pressure, and cholesterol, sleep problem and psychological symptoms of depression and anxiety.

 According to the study by Desai BN, Maharjan RH, Nampoothiri LP. almost 70% of PCOS women have abnormal serum lipid levels (dyslipidemia) and 50% of these women are obese.

 Several classes of pharmacological agents have been used to manage dyslipidemia. However, studies have shown adverse effects associated with these drugs.

Compared to other risk factors, genetic preposition has been under intensified studies by many scientists. Dr. N Prapas, the lead author in the study "Genetics of Polycystic Ovary Syndrome" said, "Polycystic ovary syndrome has been proven to be a familial condition....the role of genetic factors in PCOS is strongly supported" and

" Some genes (such as Gly972Arg, CAPN10) have shown altered expression suggesting that the genetic abnormality in PCOS affects signal transduction pathways controlling steroidogenesis, steroid hormones action, gonadotrophin action and regulation, insulin action and secretion, energy homeostasis, chronic inflammation, and others".

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. 

The plant has become very popular for commercial cultivation due to its health benefits. 

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. 

The herb also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

In the finding a natural ingredient or whole food for the treatment of polycystic ovarian syndrome (PCOs) with no side effects, researchers examine the effects of Aloe vera in Charles Foster female rats induced-PCOs PCOS by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days).

All rats before injection of the Aloe vera expressed a significant increase of hyperglycemia and 90% rats also showed elevated plasma triglycerides, elevated LDL cholesterol levels, and lowered plasma HDL cholesterol levels, an indication of a dyslipidemic profile.

PCOS positive rats with an aberrant lipid profile were selected to the treatment with AVG formulation (1 ml (10 mg)/day, 30 days) administered orally.

Infection of AVG in PCOS rats exhibited a significant reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol.

The gel treatment also completely restore the abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities.

These results firmly suggested AVG which contains a high amount of phyto components processes an anti-hyperlipidemic effect not only on PCOS but also the associated metabolic complication: dyslipidemia.

Continuously, in the study included five-month-old Charles Foster female rats were orally fed with letrozole, a non-steroidal aromatase inhibitor, to induce PCOS, researchers once again confirmed that
* Aloe vera gel formulation (1 ml dose daily for 45 days) restores their estrus cyclicity, glucose sensitivity, and steroidogenic activity.

* Co-treatment of the inductive agent (letrozole) with the Aloe vera gel prevented the development of the PCO phenotype caused by the injection of the inductive agent (letrozole).

Dr.Maharjan R, the lead author at the final day of the experiment said, " Aloe vera gel formulation exerts a protective effect in against the PCOS phenotype by restoring the ovarian steroid status, and altering key steroidogenic activity".

Taken altogether, Aloe Vera may be considered a functional food for the prevention and treatment of
polycystic ovarian syndrome (PCOs) without inducing any side effects,

However, oral administration in high amounts of Aloe vera should only be prescribed by the experts in the related field

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) ALOE VERA by Gertrude Baldwin,
(3) Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model (PubMed)

(4) Genetics of Polycystic Ovary Syndrome by N Prapas, A Karkanaki, I Prapas, I Kalogiannidis, I Katsikis, and D Panidis. (PMC)

1 comment:

  1. Anemoside B4 is extracted from the herb of Pulsatilla chinensis (Bge.) Regel. It inhibited the secretion of IL-10. Anemoside B4