Monday, 10 December 2018

Bioactive Compound Allicin, the Best in Normalizing High Blood Pressure

By Kyle J. Norton

Scientists may have found a natural bioactive ingredient for the prevention and treatment of hypertension with no side effects, according to the studies.

Hypertension is a medical condition characterized by abnormally high blood pressure.

Acute high blood pressure is a rise of high blood pressure caused by sudden stress or physical activity in a short-term that will eventually fall back to the normal levels.

Chronic hypertension is a persistence if elevated high blood pressure which cannot be decreased without medication.

Chronic hypertension is one of the members of the cluster of conditions associated with metabolic syndrome and a major cause of cardiovascular disease.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

Some researchers suggested that hypertension may be caused by certain medical conditions, such as kidney disease, however, the cause of the syndrome is more likely as a result of an unhealthy lifestyle.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects.

Therefore, if you are currently taking medicine for the treatment of hypertension, please make sure you know all side effects for preventive measure.

Dr. Beilin LJ, at the University Department of Medicine, and West Australian Heart Research Institute in the examine the lifestyle risk of hypertension wrote, High salt intakes remain a major contributor to hypertension, especially when potassium intake is low. Smoking has a dominant effect in increasing cardiovascular risk in hypertensives ".

 And, "Clustering of risk factors is often associated with clustering of unhealthy lifestyle characteristics and both are most prominent in lower socio-economic groups and in Developing Countries adopting a more sedentary lifestyle and Western diet patterns".

This statement clearly suggested that making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.

On finding a natural compound for the prevention and treatment of high blood pressure, one of a major condition associated with the onset of cardiovascular disease, researchers examined the antihypertensive phytochemical allicin isolated from garlic.

The study included nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg).

Administrated garlic preparation including 1.3% allicin at a large dose (2400 mg) showed a sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose.

From 5-14 hours after the dose, the preparation significantly decreased the diastolic blood pressure with no side effects.

Dr. McMahon FG, the lead scientist said, "Our results indicate that this garlic preparation can reduce blood pressure", after taking into account other factors.

Furthermore, in a total of 84 men with mild or moderate arterial hypertension, researchers compared the antihypertensive effects of time-released garlic powder tablets (Allicor) with that of regular garlic pills (Kwai)in a double-blind, placebo-controlled trial with an active control arm.

After an 8-week placebo treatment run-in phase, patients were randomized either to 600 mg Allicor (n=30) or to placebo (n=20) daily for 8 weeks and In addition, in the open-label branch, patients received either 2400 mg Allicor daily (n=18) or 900 mg Kwai daily (n=16).

Allicor treatment at a dose of t600 mg daily showed a decrease of both systolic and diastolic blood pressures by 7.0 mm Hg (95% confidence interval (95% CI): 5.3-8.7) and 3.8 mm Hg (95% CI: 2.7-4.8), respectively.

However, Increasing the Allicor dosage to 2400 mg daily did not provide any additional benefit.

Treatment with Kwai exerted a similar effect in decreasing systolic blood pressure (5.4 mm Hg, 95% CI: 1.9-8.8) as those of Allicor, but no decrease in diastolic blood pressure.

The results clearly indicated that Allicor may process the prolonged action that was found in the Kwai treatment group.

Dr. Sobenin IA, the lead scientists wrote in the final report, "time-released garlic powder tablets are more effective for the treatment of mild and moderate arterial hypertension than are regular garlic supplements".

Taken altogether,  allicin, a bioactive compound processed antihypertensive property may be used for the prevention and treatment of high blood pressure, pending to the validation of a large sample size and multicenter study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Can garlic lower blood pressure? A pilot study by McMahon FG, Vargas R.(PubMed)
(2) Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension by Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. (PubMed)
(3) Lifestyle and hypertension--an overview by Beilin LJ. (PubMed)

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