Cruciferous vegetables may be the next pharmaceutical target to find the effective ingredients for the treatment of cancers, some scientists suggested.
Cancers are the class of medical condition caused by the irregular cell growth with the alternation of DNA.
Primary cancers are cancers that start at the original site. What causes the cells of the tissue or organs to become cancerous are unknown. Researchers do not know why people with the same health conditions, family history, and diet some are susceptible to the cell DNA alternation while most do not.
Genetic mutation inherited from the parents is one of the major risk factors have been found to some of the cancer patients. According to the statistic, gene mutations are associated with 7% of all cancer cases in the US.
By targeting the gene that initiates the onset of cancer and its specific dysregulated molecular pathways patients may have a higher chance to inhibit the growth and spread of a tumor.
However, most people who carry the cancerous gene do not know they have them. Dr. Jain Rin the study " The Relevance of Hereditary Cancer Risks to Precision Oncology: What Should Providers Consider When Conducting Tumor Genomic Profiling?" said, "Through tumor genomic profiling (TGP), existing and novel treatments can be selected to better target the specific dysregulated molecular pathways that drive growth and spread of a patient's tumor"
Types of mutated gene facilitated the risk of cancer include BAG3, 10q26.11, BAG3 (Bcl- BLCAP, 20q11.23, BLCAP,...
Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Its chemical constituents include glucosinolates, dithiolthiones, indoles, glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..
In the study to evaluate the naturally occurring sulforaphane (SF) anti-cancer effects, researchers at the Roswell Park Cancer Institute launched an investigation to examine the SF isolated from cruciferous vegetables administered to rats orally either in a single dose or once daily for 7 days.
Where CSCs are suggested to be responsible for initiating and maintaining cancer, and to contribute to recurrence and drug resistance.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention by Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y.(PubMed)
(2) Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts by Li Y, Zhang T.(PubMed)
(3) The Relevance of Hereditary Cancer Risks to Precision Oncology: What Should Providers Consider When Conducting Tumor Genomic Profiling? by Jain R1, Savage MJ1, Forman AD1, Mukherji R1, Hall MJ. (PubMed)