Friday, 28 December 2018

Herbal Aloe Vera Gobbles Up Cancer Cells in Vivo and Vitro

By Kyle J. Norton

Aloe Vera may be the next target for the pharmaceutical companies to extract a single ingredient for the treatment of cancers, some scientists suggested.

Cancers are a class of medical diseases associated with cell growth irregularly and disorderly in some specific tissue and organs.

Most cancer starts at the cell on the surface of the inner lining of organ's tissue. At the later stage, cancer cells can be found in the deeper of layers of the infected organ.

In the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy tissue and organ through the circulation of fluids and blood.

The causes of cancer are the results of the alternation of healthy cell DNA. Researchers do not why the health cells DNA are alternated.

Normally, healthy cells undergo a certain number of cell cycle divisions than die. In a cancerous cell, cell division undergoes indefinitely.

According to the statistic, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

The genetic mutation of the cancer cell may be associated with certain risk factors. Epidemiological studies suggested that long-term exposure to carcinogens, the increased in age, gender, inherited genetic defects and skin type can increase the risk the cancer onset.
Most common and general symptoms of cancer are an unintended weight loss, lump, fatigue, loss of appetite and persistent localized symptoms and localized pain in the later stage.

If you experience some of the above symptoms, please check with your doctor right the way to rule out the possibility of cancer.

Out of numbers of the risk factor, genetic preposition has been under intensive studied by many scientists.

Dr. Eric T, the lead author in the study of genetic implication on the cancer risk said, "Genetic testing for inherited cancer risk is now widely used to target individuals for screening and prevention" and

"Overall, 17,340 PVs were identified in 17,000 (6.7%) of the tested individuals. The pathogenic variants (PV) positive rate was 9.8% among individuals with a personal cancer history, compared to 4.7% in unaffected individuals. PVs were most common in BRCA1/2 (42.2%), other breast cancer (BR) genes (32.9%), and the LS genes (13.2%)".

These results clearly stated that people who carry certain mutated genes are at the substantial risk of cancer onset, compared to those who do not.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

 It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera are amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

In the finding, a natural ingredient for the treatment of breast cancer without inducing side effects, researchers at the National Chung Hsing University conducted a study to compare the efficacy of Emodin and Aloe-Emodin, the major bioactive compound found in herbal Aloe Vera.

By analyzing the estrogenic activity as phytoestrogens on the estrogen receptor α (ER α ) activation and breast cancer cell growth, application of both emodin and aloe-emodin are capable of inhibiting breast cancer cell proliferation by reducing the ER α protein levels which has been found in high levels in patient with breast cancer thereby suppressing ER α transcriptional (mRNA) activation..

High expression of ERα mRNA is found associated with patients with breast cancer.

Breast cancer treatment with aloe-emodin also decreases the expression of the levels of ERα associated with the protein that stimulate the division of breast cancer cells by increasing the cancer cells degradation.

The efficacy of aloe-emodin inhibited breast cancer proliferation and induced apoptosis is attributed to the breaking down the cytoplasm of ER α protein in the breast cancer cells.

The results suggested that aloe-emodin suppressed breast cell proliferation emodin by targeting ER α protein expression through distinct mechanisms.

Further demonstration of the effect of aloe-emodin on the risk of cancer, researchers examined whether aloe emodin exerts a similar effect on the growth of human cervical cancer cells, HeLa.

Human cervical cancer cells, HeLa used in the experiment was treated by different doses of aloe emodin for 1-5 days,.

Measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay, aloe-emodin displays significant effects in the inhibition of the growth of HeLa cells in a dose-dependent manner at concentrations ranging between 2.5 and 40 micromol/L. 

Aloe-emodin induces HeLa cells death by disrupting the cell cycle division at the G2/M phase, according to the flow cytometric analysis.

The effects of aloe emodin inhibited the human by increasing the expression of proteins associated with cell death programming and reducing the expression of proteins associated with cancer prefiltration and survival. 

Most importantly, after taking into account co and confounders, researchers discovered, aloe-emodin also activates the enzyme associated with the break down the protein of  ER α and deactivates the enzyme associated with cell proliferation

Taken altogether,  Aloe vera with the abundant aloe-emodin may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for treatment of cancer without inducing adverse effects.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) ALOE VERA by Gertrude Baldwin,
(2) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition.
Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(3) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin. by Guo J, Xiao B, Zhang S, Liu D, Liao Y, Sun Q.(PubMed)
(4) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. by Guo JM, Xiao BX, Liu Q, Zhang S, Liu DH, Gong ZH.(PubMed)
(5) Clinical testing with a panel of 25 genes associated with increased cancer risk results in a significant increase in clinically significant findings across a broad range of cancer histories by (Research Gate)

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