Scientists may have found a legume which processes a potential in reducing the risk and treatment of gastric/ stomach cancer.
Gastric cancer is a medical condition caused by irregular cells growth in the stomach.
Most cases of gastric cancer start by the DNA alternation in the cells on the surface of the inner lining of the stomach. The stage of gastric cancer is depended to how far the cancer cells have penetrated in the deeper tissue of the stomach.
At the advanced stage, invasive cancer can leave the stomach and travel a distance away to infect other healthy tissue and organs.
Most people with primary cancer have an increased risk of secondary cancers of the thyroid and small intestine.
The most common causable risk factor of gastric cancer is infection with a common bacteria, H. pylori, which were found to cause ulcers and Inflammatory gastritis,.
Some researchers suggested that long-term untreated pernicious anemia and growth of polyps are also associated with the increased risk of gastric cancer.
It is believed that black bean was first domesticated growth in South America.
The chemicals constituents of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.
Scientists at the Gyeongsang National University School of Medicine in the findings a natural ingredient for the prevention and treatment of gastric cancer conducted an experiment to evaluate the effect black bean in risk of infection associated to the onset of gastritis, peptic ulcers, and gastric cancer.
Exposed gastric mucosa to H. pylori, showed a significant increase of gastric mucosal inflammatory cytokine interleukin-8 (Il-8) and reactive oxygen species.
In the examine the chemopreventive effects of black soybean extract against human AGS gastric cancer cells, researchers showed that
* The black soybean extract inhibited AGS cell growth in a dose-dependent manner with an IC(50) of 3.69 mg/mL as measured by the MTT assay.
* black soybean extract dose-dependently induced apoptosis of AGS cells.
Additional differentiation found that the effects of black soybean extract in inducing apoptosis were attributed to the activation of proteins associated with programming cell deaths.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-gastric cancer possibilities.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments by Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Anthocyanins from black soybean inhibit Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Kim JM, Kim KM, Park EH, Seo JH, Song JY, Shin SC, Kang HL, Lee WK, Cho MJ, Rhee KH, Youn HS, Baik SC. (PubMed)
(3) Effect of black soybean extract on the suppression of the proliferation of human AGS gastric cancer cells via the induction of apoptosis. by Zou Y, Chang SK. (PubMed)
(4) Adherence to Mediterranean diet and risk of gastric cancer: results of a case-control study in Italy. by Stojanovic J1, Giraldi L, Arzani D, Pastorino R, Biondi A, Persiani R, Boccia S, Leoncini E. (PubMed)