Monday, 24 December 2018

Black beans May Process Anti Gastric Cancer Potency, Scientists Find

By Kyle J. Norton

Scientists may have found a legume which processes a potential in reducing the risk and treatment of gastric/ stomach cancer.

Gastric cancer is a medical condition caused by irregular cells growth in the stomach.

Most cases of gastric cancer start by the DNA alternation in the cells on the surface of the inner lining of the stomach. The stage of gastric cancer is depended to how far the cancer cells have penetrated in the deeper tissue of the stomach.

At the advanced stage, invasive cancer can leave the stomach and travel a distance away to infect other healthy tissue and organs.

Most people with primary cancer have an increased risk of secondary cancers of the thyroid and small intestine.

Gastric cancer affects 2.1% of male cancer patients and 1.3% of female cancer patients in Canada.

In the later stages, stomach cancer has a 5-year survival rate of only 23%, meaning that 77% of stomach cancer patients die within 5 years of diagnosis.

The most common causable risk factor of gastric cancer is infection with a common bacteria, H. pylori, which were found to cause ulcers and Inflammatory gastritis,.

Some researchers suggested that long-term untreated pernicious anemia and growth of polyps are also associated with the increased risk of gastric cancer.

In the concerns of a poor diet in the risk of gastric cancer, Dr. Stojanovic J, the lead author at the joint study lead by the Università Cattolica del Sacro Cuore launched an investigation to examine the effects of Mediterranean diet in gastric cancer.

By comparing the different type of diet, Mediterranean diet consists of high consumption of fruit, vegetables, cereals, legumes, nuts, seeds, fish, other seafood, and olive oil lowers the risk of gastric cancer.

The risk gastric cancer increased substantially in participants who follow the Western diet rich in saturated and trans fat, red meat and processed foods.

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belongs to the family Fabaceae and can be bought in most grocery stores all around the year in dried and canned forms.

It is believed that black bean was first domesticated growth in South America.

The chemicals constituents of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

Scientists at the Gyeongsang National University School of Medicine in the findings a natural ingredient for the prevention and treatment of gastric cancer conducted an experiment to evaluate the effect black bean in risk of infection associated to the onset of gastritis, peptic ulcers, and gastric cancer.

Exposed gastric mucosa to H. pylori, showed a significant increase of gastric mucosal inflammatory cytokine interleukin-8 (Il-8) and reactive oxygen species.

In the infected gastric mucosa, application cation of Anthocyanins exerted a strong anti-oxidative, antibacterial and anti-inflammatory properties by decreasing H. pylori-induced ROS enhancement.

Furthermore, Anthocyanins protected the gastric cells by inhibiting phosphorylation of mitogen-activated protein kinases, which plays an important role involved in directing cellular responses to a diverse array of stimuli, translocation of nuclear factor-kappa B which promotes cell division and survival and Iκβα which blocks the apoptosis in response to death signals activated by proinflammatory cytokines degradation.

Moreover, Anthocyanins also inhibited H. pylori-induced inducible nitric oxide synthases in the promotion of the expression of proinflammation and cyclooxygenase-2 mRNA expression in the alternation of DNA of gastric cells.

The inflammatory IL-8 expression was also found to decrease by 48% after Anthocyanins injection.

In the examine the chemopreventive effects of black soybean extract against human AGS gastric cancer cells, researchers showed that
* The black soybean extract inhibited AGS cell growth in a dose-dependent manner with an IC(50) of 3.69 mg/mL as measured by the MTT assay.

* black soybean extract dose-dependently induced apoptosis of AGS cells.

Additional differentiation found that the effects of black soybean extract in inducing apoptosis were attributed to the activation of proteins associated with programming cell deaths.

The findings suggested black beans could be used as an apoptosis inducer in AGS cells and a natural chemopreventive agent in the treatment of human gastric cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-gastric cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments by Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Anthocyanins from black soybean inhibit Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Kim JM, Kim KM, Park EH, Seo JH, Song JY, Shin SC, Kang HL, Lee WK, Cho MJ, Rhee KH, Youn HS, Baik SC. (PubMed)
(3) Effect of black soybean extract on the suppression of the proliferation of human AGS gastric cancer cells via the induction of apoptosis. by Zou Y, Chang SK. (PubMed)
(4) Adherence to Mediterranean diet and risk of gastric cancer: results of a case-control study in Italy. by Stojanovic J1, Giraldi L, Arzani D, Pastorino R, Biondi A, Persiani R, Boccia S, Leoncini E. (PubMed)

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