Tuesday, 25 December 2018

Ginger, The Anti Gastrointestinal Disorder Functional Pungent Spice

By Kyle J. Norton

Scientists may have found a kitchen pungent spice for the treatment of the gastrointestinal disorder, some studies suggested.

Gastrointestinal diseases are the conditions of the digestive system associated with the disorders involving the gastrointestinal tract, including esophagus, stomach, small intestine, large intestine, and rectum.

The digestive system includes gastrointestinal tract (GI), liver, pancreas, and gallbladder with a healthy function of breaking down food into nutrients and fluids for the body need.

There are many different types of gastrointestinal diseases, including irritable bowel syndrome (IBS), Crohn's disease, celiac disease, and lactose intolerance.

There are many causes of gastrointestinal disorders, such as bacterial and viral infection, inflammation, poor circulation to the intestines, muscle dysfunction, gallstones, stress, particularly long-term use of anti-inflammatory drugs.

Conventional medicine used for the treatment of gastrointestinal disorders are depending on the disease that triggers the disorder.such as antibiotics for bacterial infection, painkillers for stomach pain.

 Sherry Coleman Collins, MS, RDN, LD in the article, Natural Remedies for Digestive Disorders outlined the percentage of the use of natural remedies for the treatment of gastrointestinal disorders, and how much money that the American spend a year in purchasing these remedy.

Believe or not, it is equivalent to about one-third of out-of-pocket dollars spent on prescription drugs.

The dietitian wrote, " more clients and patients are looking for ways to treat their digestive disorders with natural medicines sold over the counter. According to a 2007 National Institutes of Health-funded survey on the use of complementary and alternative medicines in the United States, roughly 38% of adults use natural remedies, such as diet-based therapies (eg, gluten-free diets) and herbs, among others" and 

"Also in 2007, it was estimated that nearly $34 billion was spent on complementary and alternative medicines, including about $15 billion on “nonvitamin, nonmineral, natural products:.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The pungent spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reconfirm the traditional use of ginger against various gastric ailments, researchers at the Tehran University of Medical Sciences conducted an experiment to review the ginger effect in the prevention of antituberculosis-induced gastrointestinal adverse reactions.
A randomized pilot clinical trial included 60 patients who were placed into ginger and placebo groups (30 patients in each group) received either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks. 

After examining the Patients' gastrointestinal complaints (nausea, vomiting, dyspepsia, and abdominal pain) and antituberculosis drug-induced hepatotoxicity were recorded during the study period, researchers showed that application ginger to the 48 (80%) patients experienced nausea caused by antituberculosis drug-induced gastrointestinal adverse reactions, reduced gastrointestinal disorders by 56% compared to 43% in the placebo.

Patients in the ginger group experienced less, but not statistically significant, antituberculosis drug-induced hepatotoxicity than the placebo group (16.7% vs 36.7%, respectively, p = 0.07).

Dr. Emrani Z, the lead author in the final report wrote, "ginger may be a potential option for prevention of antituberculosis drug-induced gastrointestinal adverse reactions including hepatotoxicity".

Additionally, in the concern of the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract, a joint study led by the North Carolina Agricultural and Technical State University was conducted to examine the ginger effect in reducing the risk of gastrointestinal disorder caused by injection of low dose aspirin.

Injection of ginger exerted a strong activity in the ameliorated ASA-induced gastric ulceration.

[6]-gingerol aspirinate (GAS), the combination of ginger bioactive compound [6[-gingerol and aspirin demonstrated anti-cancer properties in vitro and superior gastroprotective effects in mice.

The combination (GAS) was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release ASA and [6]-gingerol. 

GAS inactivates both COX-1 and COX-2 equally to reduce symptoms of inflammation and pain caused by ASA-induced gastric ulceration.

The findings suggested that ginger processes gastroprotective effects and GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa.

Taken altogether, ginger with abundant gingerols may be considered a functional food for the prevention and adjunct therapy for the treatment of gastrointestinal disorder with no side effects.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
ealth article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions Including Hepatotoxicity: A Randomized Pilot Clinical Trial by Emrani Z1, Shojaei E2, Khalili H. (PubMed)
(3) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)

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