Monday, 10 December 2018

Phytochemical Sulforaphane, The Potential Anti Colon cancer Bioactive Compound, Scientists Say

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of colon cancer with no side effects, according to studies.

Colon cancer is relatively very common and slowly growing and progressing in a predictable way.

Most cases primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

However, at the advanced stage, the tumor not only can spread to other healthy tissue and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.

The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.

According to the statistic by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The causes of colon cancer are unknown but certain risk factors, such as genetic preposition and chronic inflammation induced by colonic diseases are associated with the onset of the disease.

Some researchers suggested that the widespread of colon cancer over the past few decades probably associated with the promotion of the Western diet.

According to an article posted on WebMD By Salynn Boyles, the author said, "While there is no shortage of evidence linking the so-called Western diet to an increased risk for developing colon cancer, the study is among the first to examine the impact of such a diet on survival among patients treated for the disease".

 And,  "The findings must be confirmed, but Dana-Farber Cancer Center oncologist Jeffrey Meyerhardt, MD, a researcher on the team, says they cannot be ignored by colon cancer patients or their physicians".

The statement clearly suggested that by making a change to a healthy diet, the risk of colon cancer can be reduced substantially.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

On finding a natural bioactive compound for the treatment of colon cancer with no side effects, researchers looked into sulforaphane is an isothiocyanate that is present naturally in widely consumed vegetables and has a particularly high concentration in broccoli in the risk of colon cancer.

In rats, sulforaphane blocked the formation of tumors initiated by chemicals. The chemical compound inhibited the reinitiation of growth and decreases the cellular viability of quiescent human colon carcinoma cells (HT29).

Furthermore, sulforaphane-induced cell cycle arrest was correlated with an increased expression of a protein associated cell cycle division and cell death via an apoptotic process through cancer cells degradation.

Moreover, researchers found the anti-colon cancer cells line effect was not attributed to the proteins associated with programming cells death but activation of detoxifying enzymes.

Dr. after taking into account co and confounders, said, " (These) results strongly suggest that in addition to the activation of detoxifying enzymes, induction of apoptosis is also involved in the sulforaphane-associated chemoprevention of cancer.

Additionally, in the reaffirm the anticancer effect of the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly, researchers analyzed the formula activity against 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line).

The formula exerted a significant antiproliferative activity on all tested cancer cell lines (PC3, MCF7, and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner.

However, application of the formula at different concentrations did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts.

The result pointed out that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.

In the study to investigate the dietary isothiocyanates (ITCs) activity against HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells, researchers found that sulforaphane (SFN), a member of ITCs protect the colon tissue by inhibiting the HDAC activity and increase HDAC protein turnover.

Injection of sulforaphane (SFN) also induced colon cell growth arrest, autophagy, and apoptosis.

Further analysis of the results researcher also discovered that  ITC-induced DNA damage of colon cancer cells without causing harm to the non-cancer cells.

Taken  altogether, the findings suggested that phytochemical sulforaphane may be considered a bioactive compound for the prevention and treatment of colon cancer, pending to the  confirmation of the large sample size and multi-centers human study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells by Gamet-Payrastre L1, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Tercé F.(PubMed)
(2) GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells by Okic-Djordjevic I1, Trivanovic D, Krstic J, Jaukovic A, Mojsilovic S, Santibanez JF, Terzic M, Vesovic D, Bugarski D.(PubMed)
(3) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates by Rajendran P1, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH.(PubMed)
(4) ‘Western’ Diet Tied to Colon Cancer By Salynn Boyles (WebMD)

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