Allyl isothiocyanate, a phytochemical found abundantly in the horseradish may have a strong effect in reducing risk and treatment of bladder cancer, some studies suggested.
Every year, the disease causes over 17,000 deaths and bladder cancer is the eighth most common cause of cancer death in men.
In the study to reaffirm the effect of Allyl isothiocyanate (AITC)in the inhibition of the urinary bladder cancer growth and progression, researchers at the Department of Chemoprevention.launched
an investigation to examine the effect of the phytochemical used combination with the conventional medicine Celecoxib, a selective Cox-2 inhibitor against bladder cancer in the animal model.
The results of the efficacy of the combination was associated with the inhibition of the levels of prostaglandin E2 which not only plays an important role in the promotion of tumor growth but also is a key downstream signaling molecule of Cox-2, caspase activation in the induction of cancer cell proliferation in solid tumors and downregulation of vascular endothelial growth factor in facilitating the growth of new blood vessels to the tumor tissues.
Where AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl) cysteine, more commonly known as the N-acetylcysteine conjugate (NAC-AITC).
In an orthotopic rat bladder cancer model, NAC-AITC administered orally at 10 μmol/kg body wt inhibits cancer growth by 40% and muscle invasion by 49%.
These results are coincidently similar to those shown previously for AITC and are consistent with the understanding that NAC-AITC is a carrier of AITC.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
1. Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination by Bhattacharya A, Li Y, Shi Y, Zhang Y(PubMed)
(2) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer by Bhattacharya A, Li Y, Geng F, Munday R, Zhang Y.(PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
(4) Chronic inflammation and bladder cancer by Michaud DS. (PubMed)