Phytochemical piperine may be the next therapeutic ingredient for the prevention and treatment of cognitive impairment, some scientists suggested.
Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.
Cognitive impairment is the condition, affecting a person's thinking, communication, understanding or memory. Cognitive impairment can be acute or chronic.
There is no single cause of cognitive impairment. Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease if the brain change is caused by the abnormal clumps of beta-amyloid protein (plaques) and microscopic protein clumps of tau, Lewy bodies, if the change is a result of microscopic clumps of another protein associated with Parkinson's disease, dementia with Lewy bodies and some cases of Alzheimer's disease.
Small strokes or reduced blood flow through brain blood vessels can also cause chronic cognitive impairment.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
On finding natural ingredients for the prevention of cognitive impairment caused by oxidative damage in the brain neurons, researchers at the University Institute of Pharmaceutical Sciences examine the cognition protective effects of piperine co-administration with curcumin.
Cognitive impairment and oxidative stress mice induced by chronic stress (CS) were selected to the study.
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Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) iperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice by Rinwa P, Kumar A.(PubMed)
(2) Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression by Rinwa P, Kumar A, Garg S.(PubMed)
(3) Protective effect of curcumin and its combination with piperine(bioavailability enhancer) against haloperidol-associated neurotoxicity: cellular and neurochemical evidence by Bishnoi M, Chopra K, Rongzhu L, Kulkarni SK.(PubMed)
(4) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)