Saturday, 29 December 2018

Herbal Andrographis Modulates Immune Function To the Body Needs, Scientists Say

By Kyle J. Norton

Herbal Andrographis paniculata may have a profound effect in enhancing the function of the immune system against diseases development, some studies found.

The immune system is a set of cells which have a unique function to protect our body against antigens or infectious agents that comprises of the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

It is a made of special cells (white blood cells), antibodies, tissues (bone marrow), and organs (the spleen) defend people against germs and microorganisms every day.

There are 3 types of immunity can be classified as the following
* The innate immunity is also known as natural immunity that every human born with.

* The adaptive immunity is the type of immunity that develops in the life of the individual.

* Passive immunity that borrows from the outside sources and can only last only a short period of time

There are 2 types of immune disorders 
* Underactive immunity or immune deficiency. People with an underactive immune system are easy
to be infected  or sick all the times

* Overactive immune system or autoimmune diseases. In this case, the immune system attacks the host tissue, causing autoimmune diseases such as rheumatoid arthritis (RA).

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.

The plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.

In the finding a natural ingredient or formula for the treatment of immune dysfunction with no side effects, researchers at the Prin. K. M. Kundnani College of Pharmacy, launched an investigation to examine the immunomodulatory activity of HN-02, an extract containing a mixture of andrographolides.

The pure powder form of the mixture of andrographolides.was evaluated at 1.0, 1.5, and 2.5 mg/kg on different in vivo and in vitro experimental models.

Application of the mixture delayed-type hypersensitivity (DTH) caused by the injection of cyclophosphamide (CYP) in the mouse model.

Where cyclophosphamide (CP) is a medication used as chemotherapy and to suppress the immune system.

HN-02 treatment elevated the depressed hemagglutination antibody (HA) titer, the antibody and increased the number of plaque-forming cells (PFCs) in the spleen cells of mice caused by injection of CYP.

HN-02 treatment stimulated phagocytosis in the immune system and increased levels of white blood cells in the tested mice.

These results strongly indicated HN-02 has the ability to enhance immune function by modulating the immune responses which were altered during antigen interaction and reversing the immunosuppression induced by CYP.

Furthermore, according to the Amala Cancer Research Centre in the examine the natural whole herb function in the modulation of immune responses against tumor cells, Andrographis paniculata extract (APE) and its isolated compound andrographolide (ANDLE) exert a clinically significant effect on cell-mediated immune responses in normal and tumor-bearing control animals.

Treatment with APE and ANDLE significantly enhanced natural killer cell activity in normal and tumor-bearing animals on the fifth day,

Antibody-dependent cellular cytotoxicity was also increased in APE as well as ANDLE on day 11-treated normal and tumor-bearing animal compared to untreated tumor-bearing control animals.

Moreover, treatment of APE and ANDLE significantly elevated the production of interleukin-2 which regulates the activities of white blood cells (leukocytes, often lymphocytes) and interferon-gamma which is critical for innate and adaptive immunity in normal and Ehrlich ascites carcinoma-bearing animals.

These results firmly indicated that herbal Andrographis may be considered functional food in the enhancement of the immune function against foreign stimuli and micro pathogens.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata by Naik SR, Hule A.(PubMed)
(2) Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice by Sheeja K, Kuttan G.(PubMed)
(3) Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide by Sheeja K, Kuttan G.(PubMed)

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