Finding a cure for breast cancer from the botanical plants without inducing side effects has been a lifetime dream of many scientists. Unfortunately, as of today, the finding is still ongoing without much success.
However, according to some studies, apricot, the edible fruit may be a next pharmaceutical target to extract potential ingredients for the cure for breast cancer.
Breast cancer is a medical and chronic condition as the result of irregularly cell growth originated from the breast tissue. why women in the same health conditions, family history, and race, some are prone to develop the early onset of the disease while others do not.
Breast cancer is caused by the alternation of DNA of the cells in the breast tissue. Epidemiologically, certain prevalent factors are associated with the increased risk of the disease.
According to the probability for women to develop or die from breast cancer provided by the Canadian Cancer Statistics publication, the lifetime risk of a woman to develop is 1/8 and 1/31 of them will die from the disease.
The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae. Apricot is classified with the family of the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.
Chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides, (b),
In the reaffirming the MK615, an extract mixture containing hydrophobic substances from Japanese apricot. anti-cancer possibility, researchers at the Dokkyo University School of Medicine conducted an evaluation to examine the antineoplastic effects of MK615 against breast cancer cells.
The experiment includes 2 breast cancer cell lines, MDA-MB-468 (MDA) and MCF7, were cultured with (600, 300, and 150 mug/mL) or without MK615.
After 72 hours of incubation, researchers showed that
* MK615 inhibited the growth of MDA and MCF7 in a dose-dependent manner.
* The percentage growth inhibition of MDA at dosages of 600, 300, and 150 mg/mL was 59.2%, 52.4%, and 23.3%, respectively, and that for MCF7 was 83.5%, 52.7%, and 16.6%, respectively.
* MK615 treatment included massive vacuolization in the cytoplasm and apoptotic changes in the nucleus.
* Cell cycle analysis showed that MK615 increased the proportion of cells in the G2-M phase in both MDA (7.8-11.7%) and MCF7 (8.1-18.7%), and finally both cell lines became apoptotic.
These results suggested MK615 effectively inhibits the growth of breast cancer cells in vitro, through cell cycle arrest and apoptosis.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(a) [Studies on the chemical constituents of flowers of Prunus mume].[Article in Chinese] by Zhang QH1, Zhang L, Shang LX, Shao CL, Wu YX.(PubMed)
(1) New antineoplastic agent, MK615, from UME (a Variety of) Japanese apricot inhibits growth of breast cancer cells in vitro by Nakagawa A1, Sawada T, Okada T, Ohsawa T, Adachi M, Kubota K. (PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS. (PubMed)
(3) The Role of Diet and Lifestyle in Women with Breast Cancer: An Update Review of Related Research in the Middle East by Zainab Taha1 and Sakina E. Eltom. (PMC)