Sunday, 16 December 2018

Phytochemical Tartaric Acid Improves the Digestive Absorption and Feces Secretion

By Kyle J. Norton

Tartaric acid, an organic phytochemical may process a significant effect in improving the digestive function in the absorption of nutrients and fluids from foods intake, some scientists found.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.

In human, the digestive system consists of a set of accessory organs of digestion and the gastrointestinal tract, involving in the breakdown of food into smaller and smaller components, until they can be absorbed and assimilated into the body.

There is no single cause of the digestive disorder. the disorder can be induced by multiple factors including bacterial infection, viral infection, inflammation, lactase deficiency, intake of some difficulty digesting certain foods.

In severe cases, the digestive disorder can be caused by poor circulation to the intestines or other organs and complication of other medical conditions such as muscle dysfunction, gallstones, stress, and side effects of certain medications including the anti-inflammatory drugs.

Other common diseases that cause digestive disorder also include irritable bowel syndrome and disease, heartburn.

Most common acute symptoms of digestive disorders are bloating, diarrhea, gas, stomach pain, and stomach cramps.

Lifestyle has been found to associate with the onset of digestive disorders. Dr. Hall EH, the lead scientist in the digestive disorders team in the investigation of the effects of environmental and lifestyle on disorders of the large and small intestine, wrote, "External factors including obesity, lack of physical exercise, and tobacco consumption also impact diseases of the luminal gastrointestinal (GI) tract" and : new treatment options for celiac disease reflect the complex interaction of diet, genetic factors, and the host immune response, the implications for treatment of many conditions of the large and small intestine that arise from environmental and lifestyle are as basic as ensuring adequate nutrition, regular exercise, and cessation of tobacco use".

This statement suggested, by following a healthy diet and lifestyle with moderate exercise is one of the best methods that reduce substantially the risk of digestive disorders.

Tartaric acid is a phytochemical of the organic acid found abundantly in nuts, apricots, apples, sunflower, avocado, grapes, etc.

In the study to examine the effects of D-tartaric acid (TA) on intestinal drug absorption under both in situ and in vitro experimental conditions, researchers found that
* TA improved paracellular drug transport by changes the integrity of the epithelial tight junctions in rat colon at low pH conditions.
* Application of TA (20 mM) increased the absorption of Rho123, a chemical compound and a dye in both ileum and colon but not in the jejunum.

* TA (20 mM) also increased the absorption of daunorubicin in the ileum, but TA (20 mM) did not change the expression level of P-glycoprotein (P-gp) which processes a function in pumping foreign substances out of cells.

* TA (20 mM) significantly inhibited excretion of i.v.-administered Rho123 and daunorubicin into the ileal lumen.

These results suggested that TA increases the intestinal absorption of P-gp substrates Rho123 and daunorubicin, a chemotherapy medication used to treat cancer, by modulating the P-gp function without changing the expression level of P-gp in the rat intestine.

Futhermore, in the evaluation of the new starch preparations produced by thermolysis of potato starch in the presence of inorganic (hydrochloric) and organic (citric and tartaric) acids under controlled conditions to examine whether the new starch effect in intestinal absorption.

Dextrin D3, obtained by heating starch acidified with hydrochloric and tartaric acids exerted a strong effect in breaking down foods into simpler chemical compounds. and absorbed by the digestive tract.

The presence of high concentration of the tartaric acid at had a significantly stronger influence on chemical breakdown of a compound due to reaction with water compared to on citric acid.

The results confirmed the possibility of applying dextrins, prepared under specific conditions, as soluble dietary fiber in the promotion of colon feces movement.

Taken altogether, the Tartaric acid may be considered a function supplement in improving the digestive system in breaking down foods for absorption of nutrients and fluids for the body need and
promoting the colon feces secretion.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Improvement of intestinal absorption of P-glycoprotein substrate by D-tartaric acid by Iida A, Tomita M, Idota Y, Takizawa Y, Hayashi M.(PubMed)
(2) New starch preparations resistant to enzymatic digestion by Jochym K, Kapusniak J, Barczynska R, Sli┼╝ewska K.(PubMed)
(3) Environmental and lifestyle influences on disorders of the large and small intestine: implications for treatment by Hall EH1, Crowe SE.(PubMed)

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