Sunday, 30 December 2018

Honey, The Best to Inhibits Chemo-toxicity and Improves Chemotherapy For Treatment of Cancers

By Kyle J. Norton

Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.

Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.

Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at the early stage.

However, as cancer progresses, the continued growth tumor may cause pressure on the nearby healthy organs and nerve cells, leading localized symptoms and severe pain.

At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.

According to the statistic from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

In 2017, over 15,000 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.
Chemo drugs are medicine used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organ.

Chemotoxicity is the side effects of chemo drugs.

Most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.

According to the information of the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.

The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick and easily infected.
Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food which processes chemopreventive properties and anti chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.

A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.

AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage of liver and kidney

After treatment of KH, AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by blood profile.

Furthermore, KH was not toxic identified by the KH treated group not induced with AOM.

These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs activity without inducing any side effects.

Moreover, on finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.

Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function in stimulating cancer cell multicity and activation of pathways associated to cell death programming.

Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing to harm to the nearby cells and tissue.

This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.

Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.


The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting the toxicity and cancer cells resistance.

Taken altogether, KH and MH can be considered functional foods for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hern√°ndez TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)

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