Daily intake of a portion of celery may have a potential effect in reducing the risk and treatment of colon cancer, some scientists found.
The colon is also known as the large intestine.
Colon cancer is relatively very common and slowly growing and progress cancer and in a predictable way and is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
Colon cancer is a chronic and medical condition characterized by cell growth disorderly and uncontrollably in the colon tissue.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. The stage of colon cancer is depended on how far the alternated cells have spread in the colon.
Patients with the early stage of colon cancer, may not experience any symptoms. But as the tumor spread and expanse, it may suppress the nearby tissue and nerve, causing symptoms of locally severe pain and discomforts.
Although there are many risk factors associated with the early onset of colon cancer, a poor diet high in saturated fat and trans fat, red meat and processed foods have been found to play a major role in the development and recurrence of colon cancer in the Western world.
Dr. Yun Zhu, the lead author in the study "Western Diet and Recurrence of Colon Cancer"Disease-free survival (DFS) among CRC patients was significantly worsened among patients with a highly processed meat dietary pattern (the highest vs the lowest quartile HR 1.82" and " The association between the processed meat pattern and DFS was restricted to patients diagnosed with colon cancer (the highest vs the lowest quartile: HR 2.29".
Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.
Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
In the finding, the natural ingredient for the prevention and treatment of colon cancer without inducing side effects, researchers at the Hallym Univ investigate the major compound Luteolin, a 3',4',5,7-tetrahydroxyflavone isolated from celery in a tested cancer cell line.
Luteolin exerted a strong activity in mediated regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line.
Injection of luteolin decreased DNA synthesis and viable HT-29 cell numbers in a concentration-dependent manner.
Luteolin also promoted G2/M arrest at 24 h posttreatment by downregulating cyclin B1 expression, in the promotion of cancer cell proliferation and survival.
Luteolin also exhibited an apoptotic effect by increasing the function of proteins which are responsible for programming cells death.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin by Lim do Y1, Jeong Y, Tyner AL, Park JH. (PubMed)
(3) Diet and cancer of the colon and rectum: a case-control study in China by Hu JF1, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ.(PubMed)
(4) Perillyl alcohol: applications in oncology by Belanger JT. (PubMed)
(5) Dietary patterns and colorectal cancer recurrence and survival: a cohort study by Yun Zhu,1,2 Hao Wu,1 Peizhong Peter Wang,1,2 Sevtap Savas,3,4 Jennifer Woodrow,1 Tyler Wish,3Rong Jin,5 Roger Green,3 Michael Woods,3 Barbara Roebothan,1 Sharon Buehler,1Elizabeth Dicks,6 John R Mclaughlin,7 Peter T Campbell,8 and Patrick S Parfrey. (PMC)