Wednesday, 12 December 2018

Phytochemical Sulforaphane (Dithiolthiones), the Potent Anti-Liver Disease Bioactive Compound, According to Studies

By Kyle J. Norton

Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.

Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affecting everyone from infants to older adults, including infected viri such as hepatitis A, B, C, and medication overloaded.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.

If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.

According to the statistic provided by the Canadian Liver Foundation,  approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.

This incidences of liver disease not only lead to dismiss the quality of life and life expectancy but cause a financial burden of the health care system.

Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.

Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".

And,  "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".

With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.

Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro- antioxidant protein which plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.

And CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.

Application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.

SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.

The results strongly suggested that SFN inhibited liver disease by increasing expression of antioxidant enzymes and lowing the expression of free radical as well as reducing the liver fat deposits.

Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentration (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity

Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.

Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.

The University of Rhode Island, Kingston study also suggested that SF activate Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, and glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolising enzymes in Hep G2 cells by Abdull Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2 and Ariel E Feldstein. (PMC)

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