Scientists may have found a bioactive compound in the prevention and treatment of allergy with no side effects, according to studies.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
Allergies are the result of the abnormally immune systematic response to typically harmless substances in the environment, leading to the symptoms and reaction in the nose, lungs, throat, sinuses, ears, lining of the stomach or on the skin.
Dr. Romina A. Ortiz, the lead scientist in the immunity team at the The Johns Hopkins Asthma & Allergy Center, said, " Genome-wide association studies (GWAS) has been widely employed in the field of allergic disease, and to date significant associations have been published for nearly 100 asthma genes/loci, in addition to multiple genes/loci for AD, AR and IgE levels".
On finding a natural constituent or wholefood for the prevention and treatment of allergy with no side effect, researchers at the Kinki University investigated the anti-allergy effect of the extract of the Piper nigrum leaf.
The in-depth analysis of the result suggested that 2 Two lignans of PN-ext, (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), from the piperine found in the extract, were identified as major active principles having histamine release-inhibitory activity.
Piperine-treated groups showed a strongly suppressed eosinophil infiltration, allergic airway inflammation, and airway hyperresponsiveness by inhibiting the proinflammatory cytokines and levels of immunoglobulin E and histamine.
Taken altogether, piperine, a major bioactive compound found in black pepper may be used for the prevention and treatment of allergy caused by immune overreaction.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(2) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC. (PubMed)
(3) Genetics of Allergic Diseases by Romina A. Ortiz, MS, and Kathleen C. Barnes, Ph.D. (PubMed)