Thursday, 20 December 2018

Apricot, the Potential Anti Colon Cancer Functional Fruit, Scientists Find

 By Kyle J. Norton

Apricot maybe next generation of whole food medicine for the prevention and treatment of colon cancer, some studies suggested.

Colon cancer is the medical condition characterized by cell growth disorderly and irregularly in the tissue of the colon as a result of the alternation of DNA of the healthy cells.

Most case of colon cancer starts on the surfaced cells of the inner lining of the colon tissue. However, at the later stage, the cancerous cells of the colon can travel a distance away to infect other healthy tissue and organs.

The colon also known as the large bowel or large intestine is an organ which involves the absorption of water from the small bowel contents and breaks down of certain materials in the feces into substances in which some of them to be reabsorbed and reused by the body.

The causes of colon cancer are unknown, However, researchers do know that age, family history, ethnicity, overweight or obesity, excessive alcohol drinking and long-term use of tobacco are a most common risk factor of the colon cancer.

Some researchers suggested that good and poor choice of the diet may have potential effects to reduce and contribute to the risk of colon cancer.

People who follow the Western diet not only associated to higher risk but also the recurrent risk of colon cancer onset.

Dr. Alan Moss, the lead author in the study of "The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations" wrote, "processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage.5 Furthermore, red meat was declared as probably carcinogenic to humans, and red meat was listed as a group 2A substance.4 Red and processed meats are considered significant components of a “Western” diet. Other consumed substances that are associated with an increased risk of CRC include alcohol6 and tobacco".

On the other hand in the support of the healthy diet choice in the reduction of colon cancer risk, Dr.Jessie A. Satia, the lead scientists said, "the fruit-vegetable and metropolitan patterns were associated with more healthful dietary behaviors (e.g., higher vegetable intake and lower red meat consumption), and demographic/lifestyle characteristics typically correlated with low colon cancer risk".

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae.

Apricot is classified with the family o the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

The chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.

Dr. Fahima Rashid, the lead author in the finding a natural and bioactive from food sources with no side effect suggested that the butanolic extract may have a profound effect in reducing the risk of colon cancer by inhibiting the expression of Gram-positive and Gram-negative bacteria.

The antibacterial effect of the extract was attributed to the presence of bioactive Flavonoid glycoside.

Futhermore, in the investigation of the anti-neoplastic effects of MK615, an extract from the Japanese apricot (Prunus mume), against 3 colon cancer cell lines, SW480, COLO, and WiDr, cultured with MK615, researchers found that
* MK615 inhibited growth and lysed SW480, COLO and WiDr cells in a dose-dependent manner.

* MK615 induced apoptosis after 6 h incubation, at which point the occurrence of apoptotic cells was 68.0%, 65.7% and 64.7% for SW480, COLO, and WiDr cells, respectively.

* MK615 induced cells death through massive cytoplasmic vacuoles (autophagosomes) in all three cell lines.

Dr. Mori S, the lead author wrote at the final report, "MK615 has an anti-neoplastic effect against colon cancer cells. The effect may be exerted by the induction of apoptosis and autophagy".

Taken altogether, apricot may be considered a functional food for the prevention and treatment of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of apricot anti-colon cancer possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Flavonoid glycosides from Prunus armeniaca and the antibacterial activity of a crude extract.Rashid F1, Ahmed R, Mahmood A, Ahmad Z, Bibi N, Kazmi SU. (PubMed)
(2) New anti-proliferative agent, MK615, from Japanese apricot "Prunusmume" induces striking autophagy in colon cancer cells in vitro by Mori S1, Sawada T, Okada T, Ohsawa T, Adachi M, Keiichi K.(PubMed)
(3)  The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
 Alan Moss and Kumanan Nalankilli. (Gastro enterology)
(4) Dietary Patterns and Colon Cancer Risk in Whites and African Americans in the North Carolina Colon Cancer Study by Jessie A. Satia, Marilyn Tseng, Joseph A. Galanko, Christopher Martin, and Robert S. Sandler (PMC)

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