Thursday, 9 January 2014

Phytochemicals Phytic acid and Alzheimer's disease (AD)

  Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Phytic acid (Inositol hexaphosphate) are phytichemicasl of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Alzheimer's disease is a brain disorder named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

The benefits
 In the study of the effects of Phytic acid (inositol hexakisphosphate), a phytochemical found in food grains an others, against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model. After 48-72-hour treatment, phytic acid is founf to be provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity. 2% phytic acid in drinking water for 70 days also showed a significant increase in brain levels of cytochrome oxidase and a decrease in lipid peroxidation. Other in  the study of composition and method for the treatment of Alzheimer's disease and related amyloid plaque development and reduction of amyloid plaque, amyloidosis and amyotrophic lateral sclerosis with phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination showed that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta amyloid proteins as are commonly seen in the brains of Alzheimer's patients.

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(1) Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)