Sunday, 8 October 2017

Herbal Therapy: Andrographis, A Chemotherapeutic Agent for Treatment of Breast Cancer

Kyle J. Norton


The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Herbal Andrographis paniculata may be used as therapeutic agent for treatment and drug resistance breast cancer, a study by the renowned institute suggested.

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

Breast cancer (malignant breast neoplasm) is condition characterized by abnormal cells growth in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

According to the joint study lead by the University of Kalyani, Andrographolide showed a significant inhibition of MDA-MB-231 breast cancer cell proliferation in a time- and concentration- dependent manner.

The study also found that the inhibition of breast cancer cell line proliferation with no effect on normal breast epithelial cells, through reduced oxygen species (ROS) production and increased population of apoptotic cells.

Other, in the study of the cytotoxic effect of chemical compound, 14-Deoxy-11,12-didehydroandrographolide (14-DDA), a major diterpenoid isolated from Andrographis paniculata (Burm.f.) Nees, application of the products suppressed the T-47D breast carcinoma cells caused cytotoxicity and elicited a non-apoptotic cell death.

Also in the MDA-MB-231 breast cancer cell, Andrographolide, a major chemical compound found in Andrographis exhibited a strong anti breast cancer cell growth activities in regulating the breast cancer cell proliferation, survival and progression and breast cancer metastasis through various mechanisms involved pro inflammatory pathways.

Taking together, there is no doubt that Andrographis may be used as a possible chemopreventive and chemotherapeutic agent for human breast cancers. But large amount intake should only be prescribed by herbalist.



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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line by Banerjee M1,2, Chattopadhyay S2, Choudhuri T3, Bera R2, Kumar S2, Chakraborty B2, Mukherjee SK4.(PubMed)
(2) 14-Deoxy-11,12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells by Tan HK1, Muhammad TS2, Tan ML3.(PubMed)
(3) Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-╬║B-dependent matrix metalloproteinase-9 expression by Zhai Z1, Qu X1, Li H1, Ouyang Z1, Yan W2, Liu G3, Liu X1, Fan Q1, Tang T1, Dai K1, Qin A1.(PubMed)

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