Saturday, 21 October 2017

Food Therapy: Coffee in Increased Risk of Lung Cancer Linearly

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Bad news for coffee lovers, the recent study suggested that regular coffee consumptiontion may associate to increased risk of lung cancer.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Lung cancer is a medical condition caused by irregular cell growth in the lung. At the later stage, cancer cells may spread to distant tissues and organs.

Dr. Wang Y, the lead author said, "a linear dose-response relationship exists between coffee consumption and risk of lung cancer".

In the clarified risk of coffee in induced lung cancer, the Shanghai Institute of Pharmaceutical Industry conducted a search in the data base of PubMed and Embase, from 1966 to January 2009. In 5 prospective studies and 8 case-control studies involving 5347 lung cancer cases and 104,911 non-cases selected, researchers found that
1. Coffee high amount intake was associated to a significant positive lung cancer risk
2. Risk of lung cancer increased by 14% for additional 2 cups consumed daily.

Interestingly, prospective studies conducted in America and Japan showed a significantly associated with increased risk of lung cancer in highest coffee consumption, but borderline significantly associated with decreased risk of lung cancer in non-smokers in compared to studies conducted from other countries.
And people drinking decaffeinate coffee showed a decreased risk of lung cancer in all studies.

Other, in the review of seventeen studies (5 cohort and 12 case-control studies) involving 12 276 cases and 102 516 controls met the predetermined inclusion criterion, extracted from data base of literature, the total risk of coffee intake and lung cancer incidence was 1.17 in compared to non drinkers.  Also in compared to non drinkers, the relative risk of lung cancer was associated to numbers of cup per day consumed,
1. 1.10 (95% CI: 0.92-1.31) for ⩽1 cup per day,
2. 1.10 (95% CI: 0.93-1.30) for 2-3 cups per day and
3. 1.20 (95% CI: 1.02-1.39) for ⩾3 cups per day.

More importantly, Dr. Xie Y, the lead author said, " Significant associations for high coffee intake with increased risk of lung cancer were observed in men (OR=1.41 95% CI: 1.21-1.63), but not in women (OR=1.16, 95% CI: 0.86-1.56), in American (OR=1.34 95% CI: 1.08-1.65) and Asian populations (OR=1.49 95% CI: 1.28-1.74), but not in European populations (OR=1.12, 95% CI: 0.74-1.67), and in smokers (OR=1.24, 95% CI: 1.00-1.54), but not in nonsmokers (OR=0.85, 95% CI: 0.64-1.11)".

Taking altogether, there is no doubt that regular coffee intakes of large amounts is associated linearly in increased risk of lung cancer, particularly in men and smokers.

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(1) Coffee and tea consumption and risk of lung cancer: a dose-response analysis of observational studies by Wang Y, Yu X, Wu Y, Zhang D.(PubMed)
(2) Coffee consumption and risk of lung cancer: a meta-analysis by Tang N1, Wu Y, Ma J, Wang B, Yu R.(PubMed)

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