Thursday, 26 October 2017

Food Therapy: Coffee A Potent and Functional Food in Reduced Risk and Treatment of Hyperglycemia

Kyle J. Norton

Epidemiological studies agreed that drinking coffee and coffee caffeine may have a potentially positive effect in reduced risk and treatment of hyperglycemia.

Hyperglycemia is a condition characterized by abnormal high of blood glucose in the blood stream.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

According to the Nagoya University, the study of antidiabetic effect of coffee and caffeine in spontaneously diabetic KK-A(y) mice,  given regular drinking water (controls) or 2-fold diluted coffee for 5 weeks, suggested that group treatment with coffee and coffee caffeine expressed a ameliorated development of hyperglycemia and improved insulin sensitivity in compared to water treatment group.

The efficacy of coffee and coffee caffeine in reduced risk of hyperglycemia may also be attributed to regulation of white adipose tissue mRNA levels in elevated the production of anti inflammatory mytokines.

Furthermore, researchers in the differentiation of the liver activity also found that although similar in treatment
1. Coffee injection improved the fatty liver and
2. Coffee caffeine exhibited the ameliorated hyperglycemia and  improved fatty liver.

In further to strengthen the result of the above analysis, the Nagoya University and other institution conducted a study related to the effect of coffee on pancreatic β-cells against induction of diabetes by streptozotocin (STZ), indicated that mice treated with coffee expressed a lowered or significantly lowered serum glucose concentration in compared to water ingestion group.

Dr. Kobayashi M, the lead researcher said, "coffee ingestion also suppressed the deterioration of hyperglycemia in diabetic mice which had been already injected with STZ" and "coffee ingestion prevented the development of STZ-induced diabetes and suppressed hyperglycemia in STZ-diabetic mice. Caffeine or decaffeinated coffee ingestion did not significantly suppress STZ-induced hyperglycemia".

Other, in the study of postprandial hyperglycemia as a direct and independent risk factor for cardiovascular diseases showed that injection of coffee polyphenol may improve postprandial hyperglycemia and vascular endothelial function by increasing GLP-1 release in affecting gut motility, inhibit gastric acid secretion, and inhibit glucagon secretion. and/or reducing oxidative stress.

More importantly, in a total of Nineteen subjects consumed a test meal with either a placebo- or extract coffee polyphenol CPE-containing beverage, researcher showed that treatment group displayed a significantly lower peak postprandial increase in blood glucose in compared to placebo beverage group.

According to the correlation analysis, treatment group also improved impaired Fibromuscular dysplasia (FMD) postprandial response in associated with blood glucose increase after injecion of the CPE beverage.

Taking together, there is no doubt that coffee may be considered as a functional food used as therapeutic sunstance in reduced risk and treatment of  hyperglycemia.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Coffee and caffeine ameliorate hyperglycemia, fatty liver, and inflammatory adipocytokine expression in spontaneously diabetic KK-Ay mice by Yamauchi R1, Kobayashi M, Matsuda Y, Ojika M, Shigeoka S, Yamamoto Y, Tou Y, Inoue T, Katagiri T, Murai A, Horio F.(PubMed)
(2) Coffee Ingestion Suppresses Hyperglycemia in Streptozotocin-Induced Diabetic Mice by Kobayashi M1, Kurata T1, Hamana Y1, Hiramitsu M2, Inoue T2, Murai A1, Horio F1.(PubMed)

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