Saturday, 7 October 2017

Herbal Therapy: Andrographis in Accelerated Wound Healing with Lesser Scar

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Andrographis paniculata is also known as Andrographis, is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.. .....

Wound healing is a natural response to restore injured tissues.

Andrographis paniculata leaf showed to process a significant wound healing effect in restoring injured tissues, a mentioned institute suggested.

According to the Universiti Teknologi MARA, topical application of Andrographis paniculata exerted a strong effect on the rate of wound enclosure with markedly less scar width and contained large amounts of fibroblast proliferation.

In a study of wound created in four groups of rat in posterior neck region. Blank placebo applied topically to the wounds of Group 1 and Groups 2 and 3 dressed with placebo containing 5% and 10% extracts of A. paniculata, groups treated with topical showed a rate of wound healing significantly accelerated in the wound dressed compared to placebo group.

The wound healing is also increased collagen and less formation of new blood vessels with absence of inflammatory cells.

Other study, in the evaluation of the effects of andrographis wound healing activity of Swiss Wistar strain rats with either sex with  topical application, 2%w/w ointment of ethanol extract and petroleum ether extract prepared in 2% w/w PEG-4000 in comparison to the left untreated control group, treatment groups showed a faster rate of complete healing in day 12 after topical application with wound contractions in petroleum ether extract, ethanolic extract were at 10.17 and 16.33, respectively.

Dr. Arnabaditya Mohanty, the lead authors in the joint study said, "Andrographis peniculata ethanolic extract possesses better wound healing property in comparison to control and also with petroleum ether extract".

Taking together, topical application of Andrographis paniculata leaf and extract may be used as a wound healing agent in accelerately restored injured tissues with lesser scar without induced adverse effects.

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(1) Effect of Andrographis paniculata leaf extract on wound healing in rats by Al-Bayaty FH1, Abdulla MA, Abu Hassan MI, Ali HM.(PubMed) and(University of Malaya)
(2) Preliminary Pytochemical Screening and Wound Healing Activity of Andrographis Peniculata by Arnabaditya Mohanty1 , Dusmanta Kumar Pradhan1 , Manas Ranjan Mishra1 , Jitendra Kumar Sahoo1 , Ashutosh Mishra *2, Bankim Chan(Journal of Chemical and Pharmaceutical Research)

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