Friday, 27 October 2017

Food Therapy: Coffee and Coffee Caffeine in Reduced Risk and Treatment of Oral Cancer

Kyle J. Norton

Coffee and coffee caffeine may have a profound effect in reduced risk and treatment of oral cancer, a renowned cancer society study suggested.

Oral cancer is a medical condition characterized by cell growth disorderly and irregularly in the mouth region, including the lips, tongue, cheeks, floor of the mouth, hard and soft palate, sinuses, and pharynx. At he later stage, infectious cells may travel a distance away from the original site to other tissues and organs.

Coffee, second to green tea is one most popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In a prospective US cohort study begun in 1982 by the American Cancer Society, including 968,432 men and women with cancer free at enrollment, 868 deaths due to oral/pharyngeal cancer occurred during 26 years of follow-up, researchers file the following results, without modifying other factors such as sex, smoking status, or alcohol use.
1. In compared to no/occasional drinkers, patients drinking more than 4 cups of caffeine coffee per day showed a risk of oral/pharyngeal cancer death reduced by 49% with relative risk of cancer developing of .51.
2. Also in compared to the no and occasional groups, patients drinking more than 4 cups of coffee per day had a relative risk ratio of .61.

According to the Epidemiology Research Program, American Cancer Society, intake of caffeinated coffee showed a significantly inverse association in reduced risk and motility of oral/pharyngeal cancer, linearly in dose depending manner.
Additionally, in data extracted from the Miyagi Cohort Study in Japan, including 38,679 subjects aged 40-64 years with no previous history of cancer, 157 cases of oral, pharyngeal, and esophageal cancers identified during 13.6 years of follow-up, returned food frequency questionnaires from participants expressed the results as follow
1. Patients consumed > or =1 cups of coffee per day had a relative risk ratio of .51 in compared to no drinkers. group.
2. In take of caffeine coffee showed a inverse association with cancer incidence, regardless of sex and cancer site.

More interestingly, the study also emphasized that risk of cancer reduced in caffeine coffer consumption, even with people have been identified with high risk in cancer developing.

Dr. said, 'Hazard ratios were estimated by the Cox proportional hazards regression model. The risk of oral, pharyngeal, and esophageal cancers was inversely associated with coffee consumption".

More importantly, in support of the above analysis, the study on cases of esophageal cancer(395) in compared to 1066 cases of controls conducted by the Istituto di Ricerche Farmacologiche "Mario Negri" proposed that the same relative risk of  0.6  in both  oral/pharyngeal, and  esophageal cancer also found in subjects, drinking over >3 cups/ day. And there was no association between caffeine coffee in expression of reduced risk of cancers.

Taking altogether. coffee and coffee caffeine have a potential use as functional and therapeutic product in reduced risk and treatment of oral cancer. But Dr. Hildebrand JS, the lead author said, "Research is needed to elucidate biologic mechanisms whereby coffee might help to protect against these often fatal cancers.". 

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Coffee, tea, and fatal oral/pharyngeal cancer in a large prospective US cohort by Hildebrand JS1, Patel AV, McCullough ML, Gaudet MM, Chen AY, Hayes RB, Gapstur SM.(PubMed)
(2) Coffee consumption and the risk of oral, pharyngeal, and esophageal cancers in Japan: the Miyagi Cohort Study by Naganuma T1, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, Nishino Y, Fukao A, Tsuji (PubMed)

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