Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
Coffee and coffee caffeine may have a direct effect in mutagenicity in bacteria and fungi, but lesser in mammalian cells, a France study suggested.
According to the Université de Nancy, Coffee and caffeine showed a significant effect in gene mutation in bacteria and fungi, but in high concentrations, they expressed also a similarly mutagenic influence to mammalian cells in culture.
The mutagenic activity of caffeine can be observed through its potentiate in induced chromosomal aberrations through transforming sublethal damage of mutagenic agents into lethal damage. But conversely, intake of coffee and caffeine denostrated a protective effect in inhibit these mutagenic properties through theirs' numerous chemicals depending to the time consumption in the presence of mutagenic agent.
More importantly, coffee also exhibited chemoprotective effects of against toxic Aflatoxin B1 in duced genotoxicity in either human liver cell line and primary hepatocytes.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Potential genotoxic, mutagenic and antimutagenic effects of coffee: a review by Nehlig A1, Debry G.(PubMed)
(2) Trigonelline, a naturally occurring constituent of green coffee beans behind the mutagenic activity of roasted coffee? by Wu X1, Skog K, Jägerstad M.(PubMed)
(3) Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver by Cavin C1, Marin-Kuan M, Langouët S, Bezençon C, Guignard G, Verguet C, Piguet D, Holzhäuser D, Cornaz R, Schilter B.(PubMed)