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Coffee intake daily and regularly may have a potential effect in improved insulin resistance, thus reducing risk of early onset of diabetes, a university study proposed.
Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
In a study of the effect of coffee against insulin resistance of Male C57BL/6N mice (N = 48) divided into six dietary groups: chow diet, HFD, HFD-supplemented with 0.1%, 0.3%, and 0.9% decaffeinated green coffee bean extract, researchers found that treatment of the minimum dose 0.3%.of green coffee bean extract showed a mostly significant effect in improved insulin levels caused by HFD- diet.
Further more, decaffeinated green coffee bean extract in the study also expressed reversely fat accumulation and insulin resistance caused by HFD diet by downregulating the genes involved in adipogenesis and inflammation in fat tissues involved insulin resistance.
1. Bioactive compound isolated from coffee at 10(-8) and 10(-6) M acutely increased insulin secretion by 12% and 16% respectively.
2. Long-term exposure to cafestol at 10(-10) and 10(-8) M increased insulin secretion by 34% and 68%,
3. Caffeic acid, another compound isolated from coffee also increased insulin secretion acutely and chronically.
4. Compounds showed no association to insulin secretion, included Chlorogenic acid, trigonelline, oxokahweol, and secoisolariciresinol.
In support to the above analysis, the antidiabetic effects of coffee and caffeine on high-fat-diet-induced impaired glucose tolerance in C57BL/6J mice. C57BL/6J mice fed a high-fat diet given regular drinking water (control group), or a 2.5-fold-diluted coffee or caffeine solution (200 mg/L) for 17 weeks. indicated that group treated with injection of coffee caffeine strongly improve glucose tolerance, insulin sensitivity, and hyperinsulinemia in compared with mice in the control group.
And coffee and caffeine exerted an ameliorative effect on high-fat-diet-induced impaired glucose tolerance through reduced inflammatory expression in gene and cytokins in improving insulin sensitivity.
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(1) Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice by Song SJ1, Choi S1, Park T1.(PubMed)
(2) Cafestol, a Bioactive Substance in Coffee, Stimulates Insulin Secretion and Increases Glucose Uptake in Muscle Cells: Studies in Vitro by Mellbye FB1, Jeppesen PB1, Hermansen K1, Gregersen S1.(PubMed)
(3) Coffee and caffeine improve insulin sensitivity and glucose tolerance in C57BL/6J mice fed a high-fat diet by Matsuda Y1, Kobayashi M, Yamauchi R, Ojika M, Hiramitsu M, Inoue T, Katagiri T, Murai A, Horio F.(PubMed)