Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of various diseases, but single ingredient isolated from such plants may induce opposite responses.
Intake of coffee caffeine daily has induced conflicted results in risk of auto immune disease, systemic lupus erythematosus epidemiological studies suggested.
In the assessment of 152 SLE cases and 427 healthy controls, in Japanese women in testing the interaction of NAT2 polymorphism, acting primarily in the liver to detoxify a large number of chemicals including caffeine and consumption of beverages, researchers found that coffee with a relative risk of 1.57 showed a significant increased risk of SLE,
Mutation of gene NAT2, involved in the metabolism of several compounds relevant in pharmacology or toxicology showed a direct effect in significantly modified alcohol use and black tea consumption on SLE, but not in coffee.
Acetylator is found to associated to a relatively high incidence of systemic lupus erythematosus.
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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages by Kiyohara C1, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y; Kyushu Sapporo SLE (KYSS) Study Group(PubMed)
(2) Coffee and autoimmunity: More than a mere hot beverage!by Sharif K1, Watad A1, Bragazzi NL2, Adawi M3, Amital H1, Shoenfeld Y4.(PubMed)
(3) Lack of association between slow acetylator status and spontaneous lupus erythematosus by Kumana CR1, Chan MM, Wong KL, Wong RW, Kou M, Lauder IJ.(PubMed)