Tuesday, 17 October 2017

Food therapy: Coffee Caffeine In Risk of Systemic Lupus Erythematosus in Women with Mutation of Gene NAT2

Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of various diseases, but single ingredient isolated from such plants may induce opposite responses.

Intake of coffee caffeine daily has induced conflicted results in risk of auto immune disease,  systemic lupus erythematosus epidemiological studies suggested.

In the assessment of 152 SLE cases and 427 healthy controls, in Japanese women in testing the interaction of NAT2 polymorphism, acting primarily in the liver to detoxify a large number of chemicals including caffeine and consumption of beverages, researchers found that coffee with a relative risk of 1.57 showed a significant increased risk of SLE,

Mutation of gene NAT2, involved in the metabolism of several compounds relevant in pharmacology or toxicology showed a direct effect in significantly modified alcohol use and black tea consumption on SLE, but not in coffee.

These findings suggested that certain beverages may have an implication in elevated gene change in risk of systemic lupus erythematosus, such as alcohol in reduced but black tea in increased risk of systemic lupus erythematosus.

Other, in the evaluated possibility of environmental lupus erythematosus provocative substances eliminated by acetylation in 36 Chinese women with mild, stable, and confirmed lupus erythematosus and 36 healthy control subjects matched for age, sex, and ethnic origin, researchers at the University of Hong Kong. found that 1 - 4 hours after drinking a strong cup of coffee (caffeine), there was no association between slow acetylator status and lupus erythematosus in the both study subjects.

Acetylator is found to associated to a relatively high incidence of systemic lupus erythematosus. 

Taking altogether, there is no doubt that coffee caffeine only has a direct effect in increased risk of systemic lupus erythematosus in women with mutation gene NAT, but not other environmental  provocative substances. Further cohost and large sample size are necessary to reassess these implications.

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages by Kiyohara C1, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y; Kyushu Sapporo SLE (KYSS) Study Group(PubMed)
(2) Coffee and autoimmunity: More than a mere hot beverage!by Sharif K1, Watad A1, Bragazzi NL2, Adawi M3, Amital H1, Shoenfeld Y4.(PubMed)
(3) Lack of association between slow acetylator status and spontaneous lupus erythematosus by Kumana CR1, Chan MM, Wong KL, Wong RW, Kou M, Lauder IJ.(PubMed)

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